Human papillomavirus infection and esophageal cancer: a nationwide seroepidemiologic case-control study in Sweden.
Human papillomavirus infection and esophageal cancer: a nationwide seroepidemiologic case-control study in Sweden.
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人乳头瘤病毒感染和食管癌：瑞典的一项全国性血清流行病学病例对照研究。
DOI：
10.1093/jnci/91.2.156
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Nyrén,O
中科院分区：
文献类型：
--
作者：
Lagergren,J;Wang,Z;Bergström,R;Dillner,J;Nyrén,O
背景技术背景：在三项血清流行病学研究中，人乳头瘤病毒（HPV）16型感染被认为是食管鳞状细胞癌的危险因素。我们进行了一项更大规模的基于人群的研究，以验证这种关联并调查可能的混杂因素。方法：我们在瑞典进行了一项关于HPV 16或HPV 18感染与食管鳞状细胞癌或食管/胃食管腺癌风险的全国性病例对照研究。根据肿瘤的位置和组织学类型对肿瘤进行严格分类。有偶发癌症的病例受试者和基于人群的对照受试者捐献了血液样本，并就潜在的混杂因素进行了面谈。酶联免疫吸附试验用于检测HPV血清阳性。进行多变量分析以研究HPV血清阳性、教育水平、吸烟（所有烟草）状况、饮酒和癌症风险之间的关系。 研究结果：我们比较了121例食管鳞状细胞癌和173例食管腺癌或胃食管连接部与302例基于人群的对照组。与血清阴性个体相比，HPV 16血清阳性个体发生鳞状细胞癌的年龄和性别校正优势比（OR）为1.0（95%置信区间[CI] = 0.5-2.0），HPV 18血清阳性个体为0.5（95% CI = 0.2-1.1）。腺癌的相应OR分别为1.2（95% CI = 0.7-2.2）和0.2（95% CI = 0.1-0.7）。吸烟状况、饮酒量和教育水平的调整并没有改变结果。结论：我们没有发现HPV 16或HPV 18感染与任何一种食管癌之间存在正相关的证据。我们的研究结果不支持以前的研究结论。
BACKGROUND: Infection with human papillomavirus (HPV) type 16 has been implicated as a risk factor for esophageal squamous cell carcinoma in three seroepidemiologic studies. We conducted a larger, population-based study to verify this association and to investigate possible confounding factors. METHODS: We performed a nationwide case-control study in Sweden of HPV16 or HPV18 infection and risk of esophageal squamous cell carcinoma or esophageal/gastroesophageal adenocarcinoma. Tumors were strictly classified by their location and histologic type. Case subjects with incident cancers and population-based control subjects donated blood samples and were interviewed in person about potential confounding factors. An enzyme-linked immunosorbent assay was used to detect HPV seropositivity. Multivariate analyses were conducted to study relationships between HPV seropositivity, level of education, smoking (all tobacco) status, alcohol consumption, and cancer risk. RESULTS: We compared 121 case subjects with esophageal squamous cell carcinoma and 173 case subjects with adenocarcinoma of the esophagus or gastroesophageal junction with 302 population-based control subjects. The age- and sex-adjusted odds ratios (ORs) for squamous cell carcinoma were 1.0 (95% confidence interval [CI] = 0.5-2.0) for persons seropositive for HPV16 and 0.5 (95% CI = 0.2-1.1) for persons seropositive for HPV18 in comparison with seronegative individuals. The corresponding ORs for adenocarcinoma were 1.2 (95% CI = 0.7-2.2) and 0.2 (95% CI = 0.1-0.7), respectively. Adjustments for smoking status, alcohol consumption, and level of education did not alter the results. CONCLUSIONS: We found no evidence of a positive association between HPV16 or HPV18 infection and either form of esophageal cancer. Our results do not support conclusions from previous studies.
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DOI：
--
发表时间：
1997-04
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
K. Shah;R. Viscidi;A. Alberg;K. J. Helzlsouer;G. W. Comstock
通讯作者：
K. Shah;R. Viscidi;A. Alberg;K. J. Helzlsouer;G. W. Comstock
没有证据表明低风险地区的食管鳞状细胞癌中存在已知类型的人乳头瘤病毒。
影响因子：
8.4
作者：
T. Kok;K. Nooter;S. Tjong;H. Smits;J. Schegget
通讯作者：
J. Schegget
一项关于人乳头瘤病毒在挪威食道癌中的作用的前瞻性血清流行病学研究。
影响因子：
11.2
作者：
T. Bjørge;T. Hakulinen;A. Engeland;E. Jellum;P. Koskela;M. Lehtinen;T. Luostarinen;J. Paavonen;M. Sapp;J. Schiller;S. Thoresen;Zhaohui Wang;L. Youngman;J. Dillner
通讯作者：
J. Dillner
抗人乳头瘤病毒 16 型衣壳的血清免疫球蛋白 G 抗体与肛门表皮样癌的关联。
DOI：
--
发表时间：
1995
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
P. Heino;C. Eklund;Vanoohi Fredriksson‐Shanazarian;S. Goldman;J. Schiller;J. Dillner
通讯作者：
J. Dillner
DOI：
10.1093/jnci/86.7.494
发表时间：
1994-04-06
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Kirnbauer R;Hubbert NL;Wheeler CM;Becker TM;Lowy DR;Schiller JT
通讯作者：
Schiller JT