Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis.
Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis.
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多发性硬化症中脊髓中感觉运动功能的多参数MRI相关。
DOI：
10.1177/1352458512456614
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Reich DS
中科院分区：
文献类型：
--
作者：
Oh J;Zackowski K;Chen M;Newsome S;Saidha S;Smith SA;Diener-West M;Prince J;Jones CK;Van Zijl PC;Calabresi PA;Reich DS
脊髓（SC）病理是多发性硬化（MS）临床残疾的主要原因。常规磁共振成像（MRI），特别是SC-MRI病变负荷测量，包括病变计数和体积，证明与MS患者的临床状态只有适度的关系。虽然SC横截面积（CSA）与临床功能障碍的相关性优于MRI病变计数，但SC萎缩可能意味着不可逆的组织丢失。使用定量的MRI指标敏感的早期和晚期的脊髓微结构的变化，我们寻找更好的相关性的MRI措施和MS的临床状态之间的存在。我们调查是否扩散张量成像指数和磁化传递比（MTR）更好地与MS患者的临床状态比传统的SC-MRI措施。共有129名MS患者接受了3特斯拉颈椎SC-MRI和定量感觉运动功能测试，使用Vibratron-II和测力计。感兴趣区域在C3-C4之间的轴向切片上限制SC。计算了SC-CSA、分数各向异性（FA）、平均扩散率（MD）、垂直扩散率（λ）、平行扩散率（λ）和MTR。我们使用多变量线性回归来确定MRI指标和功能障碍的临床指标之间是否存在任何关联。MS受试者与健康对照组之间以及进行性与复发性MS亚型之间的所有MRI指标均存在显著差异，但λ max除外。在校正了年龄、性别、脑实质分数和SC-CSA的多变量回归模型中，MRI指数独立地解释了髋关节屈曲强度的变异性（p值：MD、λ max、λ max < 0.001; FA = 0.07），振动感觉阈值（p值：FA = 0.04; MTR = 0.05; λ = 0.06）和扩展残疾状态量表评分（p值：FA = 0.003; MD = 0.03; λ = 0.005; MTR = 0.02）。在一个大的，异质性MS样本，定量SC-MRI指数表现出独立的关联与系统特异性和全球临床功能障碍。我们的研究结果表明，研究的指标可能提供重要的信息，微结构SC的变化和MS肢体残疾的基板。确定的结构-功能关系的基础上，这些措施的潜在效用的评估治疗效果。
Spinal cord (SC) pathology is a major contributor to clinical disability in multiple sclerosis (MS). Conventional magnetic resonance imaging (MRI), specifically SC-MRI lesion load measures that include lesion count and volume, demonstrate only a modest relationship with the clinical status of MS patients. Although SC cross-sectional area (CSA) correlates better with clinical dysfunction than MRI lesion count, SC atrophy likely signifies irreversible tissue loss. Using quantitative MRI indices sensitive to early and late microstructural changes in the spinal cord, we searched for the presence of better correlations between MRI measures and clinical status in MS. We investigated whether diffusion-tensor imaging indices and the magnetization-transfer ratio (MTR) were better associated with the clinical status of MS patients than conventional SC-MRI measures. A total of 129 MS patients underwent 3-tesla cervical SC-MRI and quantitative sensorimotor function testing, using the Vibratron-II and dynamometer. Regions-of-interest circumscribed the SC on axial slices between C3-C4. We calculated SC-CSA, fractional anisotropy (FA), mean diffusivity (MD), perpendicular diffusivity (λ⊥), parallel diffusivity (λ‖) and MTR. We used multivariable linear regression to determine if there were any associations between MRI indices and clinical measures of dysfunction. All MRI indices were significantly different in subjects with MS versus healthy controls, and between the progressive versus relapsing MS subtypes, with the exception of λ‖. In multivariable regression models that were adjusted for age, sex, brain parenchymal fraction, and SC-CSA, the MRI indices independently explained variability in hip flexion strength (p-values: MD, λ⊥, λ‖ < 0.001; FA = 0.07), vibration sensation threshold (p-values: FA = 0.04; MTR = 0.05; λ⊥ = 0.06), and Expanded Disability Status Scale scores (p-values: FA = 0.003; MD = 0.03; λ⊥ = 0.005; MTR = 0.02). In a large, heterogeneous MS sample, quantitative SC-MRI indices demonstrated independent associations with system-specific and global clinical dysfunction. Our findings suggest that the indices studied may provide important information about microstructural SC changes and the substrates of limb disability in MS. The identified structure-function relationships underpin the potential utility of these measures in assessments of therapeutic efficacy.
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影响因子：
3.3
作者：
Farrell, Jonathan A. D.;Zhang, Jiangyang;Jones, Melina V.;DeBoy, Cynthia A.;Hoffman, Paul N.;Landman, Bennett A.;Smith, Seth A.;Reich, Daniel S.;Calabresi, Peter A.;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.
影响因子：
5.7
作者：
Klawiter, Eric C.;Schmidt, Robert E.;Trinkaus, Kathryn;Liang, Hsiao-Fang;Budde, Matthew D.;Naismith, Robert T.;Song, Sheng-Kwei;Cross, Anne H.;Benzinger, Tammie L.
通讯作者：
Benzinger, Tammie L.
影响因子：
11.2
作者：
McDonald, WI;Compston, A;Wolinsky, JS
通讯作者：
Wolinsky, JS
影响因子：
10.6
作者：
Rohde, GK;Aldroubi, A;Dawant, BM
通讯作者：
Dawant, BM
DOI：
10.1191/135245800701566331
发表时间：
2000-12-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Fisher, E;Rudick, RA;Simonian, NA
通讯作者：
Simonian, NA