Involvement of Oxidative Stress in Protective Cardiac Functions of Calprotectin.
Involvement of Oxidative Stress in Protective Cardiac Functions of Calprotectin.
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DOI：
10.3390/cells11071226
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发表时间：
2022-04-05
期刊：
影响因子：
6
通讯作者：
Vergely C
中科院分区：
文献类型：
--
作者：
Rochette L;Dogon G;Rigal E;Zeller M;Cottin Y;Vergely C
钙卫蛋白（Calprotectin，CLP）属于S-100蛋白家族，是由两个结合蛋白形成的异二聚体复合物（S100 A8/S100 A9）。在细胞活化时，储存在中性粒细胞中的CLP响应于炎症刺激而在细胞外释放，并作为损伤相关分子模式（DAMP）。S100 A8和S100 A9具有抗炎和抗菌特性。该复合物是Toll样受体4（TLR 4）和晚期糖基化末端（AGEs）受体的配体。在感染和炎症部位，CLP是氧化的靶点，因为它与嗜中性粒细胞衍生的氧化剂共定位。在心脏中，氧化应激（OS）反应和S100蛋白是密切相关的，并通过病理生理过程紧密相连。本文综述了S100 A8、S100 A9和CLP在炎症反应中的作用及其与血管OS的关系，并探讨了CLP在心肌保护机制中的重要性。最近的证据解释CLP作为一个关键的调制器在炎症反应中确定了这种alarmin作为一个有趣的药物靶点。
Calprotectin (CLP) belonging to the S-100 protein family is a heterodimeric complex (S100A8/S100A9) formed by two binding proteins. Upon cell activation, CLP stored in neutrophils is released extracellularly in response to inflammatory stimuli and acts as damage-associated molecular patterns (DAMPs). S100A8 and S100A9 possess both anti-inflammatory and anti-bacterial properties. The complex is a ligand of the toll-like receptor 4 (TLR4) and receptor for advanced glycation end (RAGE). At sites of infection and inflammation, CLP is a target for oxidation due to its co-localization with neutrophil-derived oxidants. In the heart, oxidative stress (OS) responses and S100 proteins are closely related and intimately linked through pathophysiological processes. Our review summarizes the roles of S100A8, S100A9 and CLP in the inflammation in relationship with vascular OS, and we examine the importance of CLP for the mechanisms driving in the protection of myocardium. Recent evidence interpreting CLP as a critical modulator during the inflammatory response has identified this alarmin as an interesting drug target.
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DOI：
10.3390/antiox10010082
发表时间：
2021-01-09
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Guarneri F;Custurone P;Papaianni V;Gangemi S
通讯作者：
Gangemi S
影响因子：
5.7
作者：
Diaz-Ochoa VE;Jellbauer S;Klaus S;Raffatellu M
通讯作者：
Raffatellu M
影响因子：
7.1
作者：
De Caterina, R;Liao, JK;Libby, P
通讯作者：
Libby, P
影响因子：
4.7
作者：
Cremasco Takano, Ana Paula;Munhoz, Carolina Demarchi;Morais Barreto-Chaves, Maria Luiza
通讯作者：
Morais Barreto-Chaves, Maria Luiza
影响因子：
3.6
作者：
Gao, Shanglan;Yang, Yan;Liu, Guowei
通讯作者：
Liu, Guowei