Involvement of RAGE and Oxidative Stress in Inflammatory and Infectious Skin Diseases.
Involvement of RAGE and Oxidative Stress in Inflammatory and Infectious Skin Diseases.
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DOI：
10.3390/antiox10010082
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发表时间：
2021-01-09
期刊：
影响因子：
--
通讯作者：
Gangemi S
中科院分区：
文献类型：
--
作者：
Guarneri F;Custurone P;Papaianni V;Gangemi S
晚期糖基化终产物的表面受体（surface receptor for advanced glycosylation end products，ERK）及其可溶性形式（soluble receptor）和内源性分泌形式（endogenous secretory receptor，EN-ERK）属于Toll样受体超家族，直接或通过与晚期糖基化终产物（advanced glycosylation end products，AGE）和晚期氧化蛋白产物（advanced oxidation protein products，AOPP）结合在炎症和自身免疫中发挥重要作用。我们回顾了皮肤疾病中的作用的文献。在这一领域的研究仍然相当有限（28篇文章），但表明参与的RAGE和RAGE相关的途径在慢性炎症性疾病（狼疮，牛皮癣，特应性皮炎，扁平苔藓），传染病（麻风病，金黄色葡萄球菌引起的皮肤病变），糖尿病皮肤，系统性硬化症和溃疡的修复过程的改变。这些数据促进了这一领域的进一步研究，这不仅有助于更好地了解疾病的发病机制，而且可能具有有趣的临床意义。事实上，当它们在复杂和多因素炎症平衡中的作用将被充分定义时，炎症和相关分子可用作疾病严重程度和/或对治疗的反应的标志物。此外，未来有希望的治疗前景可能是局部施用这些分子中的一些（例如，saccharide）以调节局部炎症反应和/或产生用于全身性治疗的抗-saccharide抗体。
The surface receptor for advanced glycosylation end-products (RAGE) and its soluble (sRAGE) and endogenous secretory (EN-RAGE) forms belong to the superfamily of toll-like receptors and play important roles in inflammation and autoimmunity, directly or through binding with advanced glycosylation end-products (AGE) and advanced oxidation protein products (AOPP). We reviewed the literature on the role of RAGE in skin diseases. Research in this field is still rather limited (28 articles) but suggests the involvement of RAGE and RAGE-related pathways in chronic inflammatory diseases (lupus, psoriasis, atopic dermatitis, and lichen planus), infectious diseases (leprosy, Staphylococcus aureus-induced skin lesions), alterations of the repairing processes in diabetic skin, systemic sclerosis, and ulcers. These data prompt further research in this field, which not only will be useful to better understand the pathogenetic mechanisms of diseases, but is also likely to have intriguing clinical implications. Indeed, when their role in the complex and multifactorial inflammatory balance will be adequately defined, RAGE and related molecules could be used as markers of disease severity and/or response to treatment. Moreover, future promising therapeutic perspectives could be topical administration of some of these molecules (e.g., sRAGE) to modulate local inflammatory response and/or the development of anti-RAGE antibodies for systemic treatment.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.numecd.2014.10.009
发表时间：
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