Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis.
Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis.
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DOI：
10.1186/1476-9255-6-10
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发表时间：
2009-04-15
期刊：
影响因子：
--
通讯作者：
Wooley PH
中科院分区：
文献类型：
--
作者：
Liang B;Song Z;Wu B;Gardner D;Shealy D;Song XY;Wooley PH
白细胞介素-6是一种多功能细胞因子，对T/B细胞分化和成熟、免疫球蛋白分泌、急性期蛋白产生和巨噬细胞/单核细胞功能至关重要。对IL-6生物学的广泛研究表明IL-6参与了RA的病理生理学和发病机制。在胶原诱导的关节炎动物模型中测试了中和小鼠IL-6活性的抗鼠IL-6 mAb。与对照mAb处理的小鼠相比，用抗IL-6 mAb预防性处理显著降低了关节炎的发病率和严重程度。与从对照mAb处理的小鼠分离的细胞相比，从抗IL-6处理的小鼠的淋巴结分离的B和T细胞的促有丝分裂应答显著降低。与对照mAb处理的小鼠的爪相比，抗IL-6处理的小鼠的爪的总体组织病理学评分显著降低，包括炎症（滑膜炎和血管翳）和糜烂（糜烂和结构）参数。在抗IL-6处理的小鼠中也观察到软骨基质组分的损失减少。总的来说，这些数据表明IL-6在类风湿性关节炎的病理生理学中起主要作用，因此支持抗IL-6 mAb治疗类风湿性关节炎患者的潜在获益。
Interleukin-6 is a multifunctional cytokine that is critical for T/B-cell differentiation and maturation, immunoglobulin secretion, acute-phase protein production, and macrophage/monocyte functions. Extensive research into the biology of IL-6 has implicated IL-6 in the pathophysiology and pathogenesis of RA. An anti-murine IL-6 mAb that neutralizes mouse IL-6 activities was tested in animal model of collagen-induced arthritis. Prophylactic treatment with anti-IL-6 mAb significantly reduced the incidence and severity of arthritis compared to control mAb treated mice. The mitogenic response of B and T cells isolated from the lymph nodes of anti-IL-6 treated mice was significantly reduced compared to cells isolated from control mAb treated mice. The overall histopathology score for paws from the anti-IL-6 treated mice was significantly reduced when compared to paws from mice treated with control mAb, including both inflammatory (synovitis and pannus) and erosive (erosions and architecture) parameters. Reduced loss of cartilage matrix components was also observed in the anti-IL-6 treated mice. Collectively, these data suggest that IL-6 plays a major role in the pathophysiology of rheumatoid arthritis, and thus support the potential benefit of anti-IL-6 mAb treatment in rheumatoid arthritis patients.
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DOI：
10.1073/pnas.95.14.8222
发表时间：
1998-07-07
影响因子：
11.1
作者：
Ohshima, S;Saeki, Y;Kishimoto, T
通讯作者：
Kishimoto, T
II型胶原蛋白诱导的小鼠关节炎。 I.主要的组织相容性复合物（I区域）链接和抗体相关。
影响因子：
15.3
作者：
Wooley, P H;Luthra, H S;Stuart, J M;David, C S
通讯作者：
David, C S
影响因子：
2.2
作者：
Seideman, J;Peritt, D
通讯作者：
Peritt, D
影响因子：
6.9
作者：
Flannery, CR;Little, CB;Jones, SA
通讯作者：
Jones, SA
影响因子：
4.9
作者：
Gabay C
通讯作者：
Gabay C