Interleukin-6 and chronic inflammation.
Interleukin-6 and chronic inflammation.
复制标题
DOI：
10.1186/ar1917
复制
发表时间：
2006
影响因子：
4.9
通讯作者：
Gabay C
中科院分区：
文献类型：
--
作者：
Gabay C
Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the acute phase response as defined by a variety of clinical and biological features such as the production of acute phase proteins. IL-6 in combination with its soluble receptor sIL-6Rα, dictates the transition from acute to chonic inflammation by changing the nature of leucocyte infiltrate (from polymorphonuclear neutrophils to monocyte/macrophages). In addition, IL-6 exerts stimulatory effects on T- and B-cells, thus favoring chronic inflammatory responses. Strategies targeting IL-6 and IL-6 signaling led to effective prevention and treatment of models of rheumatoid arthritis and other chronic inflammatory diseases.
登录
查看更多内容
影响因子：
56.9
作者：
RAMSAY, AJ;HUSBAND, AJ;KOPF, M
通讯作者：
KOPF, M
影响因子：
32.4
作者：
Romano, M;Sironi, M;Mantovani, A
通讯作者：
Mantovani, A
影响因子：
3.1
作者：
DALRYMPLE, SA;LUCIAN, LA;MURRAY, R
通讯作者：
MURRAY, R
影响因子：
16.8
作者：
Buckley, CD;Pilling, D;Salmon, M
通讯作者：
Salmon, M
影响因子：
56.9
作者：
Randolph, GJ;Beaulieu, S;Muller, WA
通讯作者：
Muller, WA