Snoring and markers of fetal and placental wellbeing.
Snoring and markers of fetal and placental wellbeing.
复制标题
打鼾以及胎儿和胎盘健康的标志。
DOI：
10.1016/j.cca.2018.06.039
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Bourjeily,Ghada
中科院分区：
文献类型：
--
作者：
Salameh,Myriam;Lee,Jennifer;Palomaki,Glenn;Eklund,Elizabeth;Curran,Patrizia;Suarez,JoseAntonioRojas;Lambert-Messerlian,Geralyn;Bourjeily,Ghada
前言打鼾是睡眠时部分气道阻塞的症状，是妊娠期常见的主诉，与不良的围产期结局有关。这种关联的机制尚未研究。我们调查了打鼾在怀孕期间和母亲的血清标记物的胎儿胎盘wellbeing.MethodsWe进行了二次分析的一项横断面研究，旨在探讨围产期的睡眠呼吸障碍的结果。系统地选择入院分娩的妇女，并使用多变量呼吸暂停预测指数回答关于打鼾的问卷。参与者有筛选标记物测量被纳入并分为打鼾者和非打鼾者。测量的标志物包括孕早期和孕中期唐氏综合征筛查标志物，报告为中位数（MoM）的倍数。一个额外的分析与打鼾者分类为急性或慢性打鼾者的基础上打鼾的持续时间与pregnancy.ResultsWhile共病产妇的医疗条件之间的打鼾者和非打鼾者的显着差异，有两组之间的新生儿结局评估没有显着差异。打鼾者和非打鼾者之间在妊娠早期（PAPP-A）或妊娠中期（AFP、uE 3、hCG、HbA 1c-A）标记物中的任何标记物均无显著差异，p> 0.25。此外，没有显着差异的标记物水平之间的急性和慢性snorers.ConclusionSnoring是不相关的标记物的胎儿或胎盘的福祉在这里测试的改变，并建议有替代机制之间的关联打鼾和不良围产期结局。
IntroductionSnoring, the symptom of partial airway obstruction during sleep, is a common complaint during pregnancy and is associated with adverse perinatal outcomes. Mechanisms underlying this association have not been studied. We investigated the relationship between snoring in pregnancy and maternal serum markers of feto-placental wellbeing.MethodsWe conducted a secondary analysis of a cross sectional study designed to investigate perinatal outcomes of sleep-disordered breathing. Women admitted for delivery were systematically selected and answered a questionnaire about snoring using the Multivariable Apnea Prediction Index. Participants who had screening markers measured were included and divided into snorers and non -snorers. Markers measured included first and second trimester Down syndrome screening markers, reported as multiples of the median (MoM). An additional analysis was performed with snorers categorized as acute or chronic snorers based on duration of snoring in relation to pregnancy.ResultsWhile significant differences were noted in co-morbid maternal medical conditions between snorers and non-snorers, there were no significant differences in the neonatal outcomes assessed between the two groups. No significant differences were noted in any of the first trimester (PAPP-A) or second trimester (AFP, uE3, hCG, inhibin-A) markers between snorers and non-snorers,p> 0.25. In addition, no significant differences in marker levels were noted between acute and chronic snorers.ConclusionSnoring is not associated with alterations in the markers of fetal or placental wellbeing tested here and suggests that there are alternative mechanisms underlying the association between snoring and adverse perinatal outcomes.
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影响因子：
9.6
作者：
Loube, DI;Poceta, JS;Mitler, MM
通讯作者：
Mitler, MM
DOI：
10.3109/14767058.2014.913131
发表时间：
2015-02-01
影响因子：
1.8
作者：
Bourjeily, Ghada;Butterfield, Kristen;Lambert-Messerlian, Geralyn
通讯作者：
Lambert-Messerlian, Geralyn
影响因子：
0.9
作者：
Calaora-Tournadre, D.;Ragot, S.;Pierre, F.
通讯作者：
Pierre, F.
影响因子：
9.8
作者：
J. P. Reichmann
通讯作者：
J. P. Reichmann
影响因子：
24.3
作者：
Bourjeily, G.;Raker, C. A.;Miller, M. A.
通讯作者：
Miller, M. A.