Microbial Quantity Impacts Drosophila Nutrition, Development, and Lifespan.
Microbial Quantity Impacts Drosophila Nutrition, Development, and Lifespan.
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DOI：
10.1016/j.isci.2018.06.004
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发表时间：
2018-06-29
期刊：
影响因子：
5.8
通讯作者：
Ja WW
中科院分区：
文献类型：
--
作者：
Keebaugh ES;Yamada R;Obadia B;Ludington WB;Ja WW
在果蝇中，微生物的结合可以促进发育或延长寿命。我们测试了营养不良期间微生物协会的影响，并表明微生物数量是苍蝇寿命的预测因子。虽然所有测试的微生物，当大量提供时，可以挽救低蛋白饮食的寿命，但单次接种的效果似乎与该微生物菌株在实验条件下茁壮成长的能力有关。微生物，死的或活的，phenocopy膳食蛋白质，并计算依赖于微生物蛋白质含量是类似的蛋白质的需求确定从苍蝇喂养的研究，这表明微生物增强宿主蛋白质营养丰富的食物。促进幼虫生长的微生物也与在苍蝇培养基上更好地茁壮成长的能力有关。我们的研究结果表明，一个意想不到的范围内的微生物物种，促进苍蝇的发展和寿命，并强调微生物数量作为一个重要的决定因素的生理和营养不良期间的寿命。微生物协会促进苍蝇长寿和低蛋白饮食的发展各种微生物可以作为营养不良期间的蛋白质来源影响的程度与微生物群的数量和生物量相关最具影响力的微生物物种只是在苍蝇培养基中茁壮成长生命周期中的营养;微生物学;微生物组
In Drosophila, microbial association can promote development or extend life. We tested the impact of microbial association during malnutrition and show that microbial quantity is a predictor of fly longevity. Although all tested microbes, when abundantly provided, can rescue lifespan on low-protein diet, the effect of a single inoculation seems linked to the ability of that microbial strain to thrive under experimental conditions. Microbes, dead or alive, phenocopy dietary protein, and the calculated dependence on microbial protein content is similar to the protein requirements determined from fly feeding studies, suggesting that microbes enhance host protein nutrition by serving as protein-rich food. Microbes that enhance larval growth are also associated with the ability to better thrive on fly culture medium. Our results suggest an unanticipated range of microbial species that promote fly development and longevity and highlight microbial quantity as an important determinant of effects on physiology and lifespan during undernutrition. Microbial association promotes fly longevity and development on low-protein diet A wide range of microbes can serve as a source of protein during undernutrition The extent of effects correlates with microbiota quantity and biomass The most impactful microbial species simply thrive on fly culture medium Nutrition in Life Cycle; Microbiology; Microbiome
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影响因子：
8.8
作者：
Clark RI;Salazar A;Yamada R;Fitz-Gibbon S;Morselli M;Alcaraz J;Rana A;Rera M;Pellegrini M;Ja WW;Walker DW
通讯作者：
Walker DW
影响因子：
--
作者：
Bren A;Hart Y;Dekel E;Koster D;Alon U
通讯作者：
Alon U
影响因子：
3.4
作者：
BAKULA, M
通讯作者：
BAKULA, M
影响因子：
1.9
作者：
Anagnostou, Christiana;Dorsch, Monika;Rohlfs, Marko
通讯作者：
Rohlfs, Marko
影响因子：
6.4
作者：
Broderick NA;Buchon N;Lemaitre B
通讯作者：
Lemaitre B