Hydrogel Micropillar Array for Temperature Sensing in Fluid.
Hydrogel Micropillar Array for Temperature Sensing in Fluid.
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DOI：
10.1109/jsen.2023.3293433
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发表时间：
2023-09
影响因子：
4.3
通讯作者：
Mustakim, Nafis
中科院分区：
文献类型：
--
作者：
Seo, Sang-Woo;Song, Youngsik;Mustakim, Nafis
关键词：
微米级的局部温度传感和控制在生物系统中具有多种应用。我们通过利用其体积变化的敏感温度依赖性，提出了微米级水凝胶柱阵列作为潜在温度探针和执行器。提出了基于软光刻的成型工艺，在玻璃基板上制造基于聚 N-异丙基丙烯酰胺 (p-NIPAAm) 的水凝胶柱阵列。金纳米棒作为光诱导加热元件嵌入水凝胶柱内，并使用近红外（NIR）光来调节局部区域的温度。首先，微柱阵列的静态响应被表征为其温度的函数。结果表明，水凝胶在其低临界溶液温度（LCST）附近具有敏感的体积转变。此外，我们还表明，通过与丙烯酰胺（AAM）共聚可以轻松调整 LCST。为了证明使用所提出的柱阵列进行时空温度测绘和调制的可行性，在水凝胶柱阵列的局部区域照射脉冲近红外光，并记录其响应。根据水凝胶柱的突然体积变化特征绘制了水中的动态温度变化，并成功证明了其使用近红外光的潜在驱动能力。考虑到该结构可以以具有高空间分辨率和高敏感温度特性的二维像素格式排列，所提出的方法和器件结构可以具有多种应用来改变和感测液体中的局部温度。这在生物系统中特别有用，其中可以以高空间分辨率调节和绘制其生理温度。
Localized temperature sensing and control on a micron-scale have diverse applications in biological systems. We present a micron-sized hydrogel pillar array as potential temperature probes and actuators by exploiting sensitive temperature dependence of their volume change. Soft lithography-based molding processes were presented to fabricate poly N-isopropyl acrylamide (p-NIPAAm)-based hydrogel pillar array on a glass substrate. Au nanorods as light-induced heating elements were embedded within the hydrogel pillars, and near-infrared (NIR) light was used to modulate temperature in a local area. First, static responses of the micro-pillar array were characterized as a function of its temperature. It was shown that the hydrogel had a sensitive volume transition near its low critical solution temperature (LCST). Furthermore, we showed that LCST could be readily adjusted by utilizing copolymerizing with acrylamide (AAM). To demonstrate the feasibility of spatiotemporal temperature mapping and modulation using the presented pillar array, pulsed NIR light was illuminated on a local area of the hydrogel pillar array, and its responses were recorded. Dynamic temperature change in water was mapped based on the abrupt volume change characteristics of the hydrogel pillar, and its potential actuation using NIR light was successfully demonstrated. Considering that the structure can be arrayed in a two-dimensional pixel format with high spatial resolution and high sensitive temperature characteristics, the presented method and the device structure can have diverse applications to change and sense local temperatures in liquid. This is particularly useful in biological systems, where their physiological temperature can be modulated and mapped with high spatial resolution.
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影响因子：
4.6
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