Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder.
Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder.
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DOI：
10.1111/bdi.12204
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发表时间：
2014-09
影响因子：
5.4
通讯作者：
Tsai SY
中科院分区：
文献类型：
--
作者：
Gildengers AG;Chung KH;Huang SH;Begley A;Aizenstein HJ;Tsai SY
本研究的目的是检查双相情感障碍（BD）对大脑结构（灰质体积）的长期影响。54名BD成人[平均（标准差）年龄= 64.4（5.4）岁]接受了脑MR成像沿着综合临床评估。使用匹兹堡大学老年神经影像学实验室（Pittsburgh，PA，USA）开发的方法提取总灰质、海马和杏仁核体积。即使在控制了当前年龄和脑血管意外（CVA）风险/负担的情况下，较低的总灰质体积与较长的BD持续时间相关。此外，长期服用抗精神病药物与较低的灰质体积有关。较低的海马体积与抗精神病药物暴露的总年数和CVA风险/负担评分相关。老年与较低的总灰质，海马和杏仁核体积。我们对老年BD患者的研究支持这样一种认识，即BD是一种神经进展性疾病，病程较长，与较低的灰质体积相关的抗精神病药物暴露较多。
The aim of the present study was to examine the long-term effects of bipolar disorder (BD) on brain structure (gray matter volumes). Fifty-four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment. Total gray matter, hippocampal, and amygdala volumes were extracted using methods developed through the Geriatric Neuroimaging Laboratory at the University of Pittsburgh (Pittsburgh, PA, USA). Lower total gray matter volumes were related to longer duration of BD, even when controlling for current age and cerebrovascular accident (CVA) risk/burden. Additionally, longer exposure to antipsychotic medication was related to lower gray matter volumes. Lower hippocampal volumes were related to total years of antipsychotic agent exposure and CVA risk/burden scores. Older age was related to lower total gray matter, hippocampal, and amgydala volumes. Our study of older adults with BD supports the understanding that BD is a neuroprogressive disorder with a longer duration of illness and more antipsychotic agent exposure related to lower gray matter volume.
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