Livestock-Associated, Antibiotic-Resistant Staphylococcus aureus Nasal Carriage and Recent Skin and Soft Tissue Infection among Industrial Hog Operation Workers.
Livestock-Associated, Antibiotic-Resistant Staphylococcus aureus Nasal Carriage and Recent Skin and Soft Tissue Infection among Industrial Hog Operation Workers.
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DOI：
10.1371/journal.pone.0165713
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Heaney CD
中科院分区：
文献类型：
--
作者：
Nadimpalli M;Stewart JR;Pierce E;Pisanic N;Love DC;Hall D;Larsen J;Carroll KC;Tekle T;Perl TM;Heaney CD
猪生产工作是家畜相关（LA-）金黄色葡萄球菌鼻腔携带以及皮肤和软组织感染（SSTI）的风险因素。无论是S。金黄色葡萄球菌鼻携带与SSTI风险增加的相关性尚不清楚。我们的目的是检查S。工业化养猪场（IHO）工人及其家庭接触者中的金黄色葡萄球菌鼻携带和近期（入组前≤3个月）SSTI症状。IHO工作人员及其家庭接触者提供了鼻拭子，并回答了一份问卷，评估自我报告的个人和职业暴露以及最近的SSTI症状。分析鼻拭子中的S。金黄色葡萄球菌，包括耐甲氧西林的S.金黄色葡萄球菌（MRSA）、多重耐药-S.金黄色葡萄球菌（MDRSA），缺乏SCN（家畜协会）和SPA型。S.在103名IHO工作人员中有19%的人和80名家庭成员中有6%的人至少有一种LA指标。最近SSTI的患病率在IHO工人中为6%，在54名未成年家庭成员中为11%（26名成年家庭成员中有0人报告SSTI）。在IHO工作人员中，鼻内MDRSA和SCN阴性S。金黄色葡萄球菌感染者报告近期SSTI为非携带者的可能性分别为8.8（95%CI：1.8，43.9）和5.1（95%CI：1.2，22.2）倍。在一个家庭中，一名IHO工作人员和一名儿童都报告了最近的SSTI，并携带了相同的S。金黄色葡萄球菌SPA型（t4976）。SCN阴性S.金黄色葡萄球菌（PR：5.0，95% CI：1.2，21.4）在IHO工人谁报告从来没有与总是戴口罩在工作中升高。虽然很少有SSTI的报道，这项研究的IHO工人和他们的家庭接触者是第一个表征之间的关系，鼻腔携带抗生素耐LA-S。金黄色葡萄球菌和SSTI。这种关系的方向和暂时性以及IHO工作人员使用口罩防止这些细菌的鼻腔携带需要进一步调查。
Swine production work is a risk factor for nasal carriage of livestock-associated (LA-) Staphylococcus aureus and also for skin and soft tissue infection (SSTI). However, whether LA-S. aureus nasal carriage is associated with increased risk of SSTI remains unclear. We aimed to examine S. aureus nasal carriage and recent (≤3 months prior to enrollment) SSTI symptoms among industrial hog operation (IHO) workers and their household contacts. IHO workers and their household contacts provided a nasal swab and responded to a questionnaire assessing self-reported personal and occupational exposures and recent SSTI symptoms. Nasal swabs were analyzed for S. aureus, including methicillin-resistant S. aureus (MRSA), multidrug-resistant-S. aureus (MDRSA), absence of scn (livestock association), and spa type. S. aureus with at least one indicator of LA was observed among 19% of 103 IHO workers and 6% of 80 household members. Prevalence of recent SSTI was 6% among IHO workers and 11% among 54 minor household members (0/26 adult household members reported SSTI). Among IHO workers, nasal carriers of MDRSA and scn-negative S. aureus were 8.8 (95% CI: 1.8, 43.9) and 5.1 (95% CI: 1.2, 22.2) times as likely to report recent SSTI as non-carriers, respectively. In one household, both an IHO worker and child reported recent SSTI and carried the same S. aureus spa type (t4976) intranasally. Prevalence of scn-negative S. aureus (PR: 5.0, 95% CI: 1.2, 21.4) was elevated among IHO workers who reported never versus always wearing a face mask at work. Although few SSTI were reported, this study of IHO workers and their household contacts is the first to characterize a relation between nasal carriage of antibiotic-resistant LA-S. aureus and SSTI. The direction and temporality of this relation and IHO workers’ use of face masks to prevent nasal carriage of these bacteria warrant further investigation.
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影响因子：
4.5
作者：
Fritz SA;Camins BC;Eisenstein KA;Fritz JM;Epplin EK;Burnham CA;Dukes J;Storch GA
通讯作者：
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