Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics.
Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics.
复制标题
连翘：植物化学、质量控制、药理学和药代动力学综述。
DOI：
10.3390/molecules22091466
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发表时间：
2017-09-04
期刊：
影响因子：
--
通讯作者：
Liu M
中科院分区：
文献类型：
--
作者：
Dong Z;Lu X;Tong X;Dong Y;Tang L;Liu M
连翘作为一种传统中药，在亚洲被广泛用作单味药和复方，主要是因为它具有清热解毒的作用。现代药理研究证明，连翘体内外均具有抗炎、抗菌、抗病毒等多种治疗作用。到目前为止，已鉴定出321种化合物，并建立了灵敏的分析方法来控制其质量。近年来，有关连翘叶及其活性成分的药代动力学研究已有报道，为其临床应用提供了有价值的信息。因此，本文系统综述了有关连翘药材的最新研究报道，并对其植物化学、药理、药代动力学及标准化程序进行了较为全面的综述，特别是对生连翘与熟连翘两种应用类型的区别进行了综述，以期为其临床应用和进一步研究提供有益的参考和指导。
Forsythiae Fructus, as a traditional Chinese medicine, has been widely used both as a single herb and in compound prescriptions in Asia, mainly due to its heat-clearing and detoxifying effects. Modern pharmacology has proved Forsythiae Fructus possesses various therapeutic effects, both in vitro and in vivo, such as anti-inflammatory, antibacterial and antiviral activities. Up to now, three hundred and twenty-one compounds have been identified and sensitive analytical methods have been established for its quality control. Recently, the pharmacokinetics of Forsythiae Fructus and its bioactive compounds have been reported, providing valuable information for its clinical application. Therefore, this systematic review focused on the newest scientific reports on Forsythiae Fructus and extensively summarizes its phytochemistry, pharmacology, pharmacokinetics and standardization procedures, especially the difference between the two applied types—unripe Forsythiae Fructus and ripe Forsythiae Fructus—in the hope of providing a helpful reference and guide for its clinical applications and further studies.
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