A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.
A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.
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DOI：
10.1371/journal.pone.0049368
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gelernter J
中科院分区：
文献类型：
--
作者：
Zayats T;Yang BZ;Xie P;Poling J;Farrer LA;Gelernter J
人格与可卡因和尼古丁依赖（CD，ND）及其共病精神病理学高度相关。然而，人们对这些关系的性质知之甚少。这项研究检查了环境（婚姻）或遗传学（单个SNP，CHRNA5 * rs16969968）是否会调节非裔和欧裔美国人（AAs，EAs）中人格与CD，ND和可卡因诱导的偏执狂（CIP）的相关性。用Logistic回归分析了1432例EAs和1513例AAs。人格评定采用NEO-PI-R，CD、ND、CIP诊断采用DSM-IV。将ND和CD作为二元特征进行检查，并将受试者分为3组：（A）未接受CIP的对照组;（B）未接受CIP的CD病例;和（C）接受CIP的CD病例。多次测试均经过Bonferroni纠正。对于EA人群中的CD和ND，婚姻状况仅在其与开放性的关系中被证明是显著的调节因素（OR = 1.90，95%CI = 1.36 - 2.64，p = 1.54e-04和OR = 2.12，95%CI = 1.52 - 2.90，p = 4.65e-06）。 对于CIP，婚姻被观察到缓和其与开放性和神经质的相关性（OR = 1.39，95%CI = 1.18 - 1.63，p = 7.64e-04和OR = 1.26，95%CI = 1.12 - 1.42，p = 1.27e-03）。 rs16969968调节的相关性是肥胖和CD（OR = 1.62，95%CI：1.23 - 2.12，p = 8.94e-04）以及CIP（当比较A组与C组时，OR = 1.21，95%CI：1.11 - 1.32，p = 4.93e-04）。 在AA人群中未观察到显著的相互作用。Bonferroni校正的显著性阈值设定为1.67e-03。人格因素在CD和CIP中的作用可能受环境和遗传因素的影响，而在ND中仅受环境因素的影响。
Personality correlates highly with both cocaine and nicotine dependencies (CD, ND), and their co-morbid psychopathologies. However, little is known about the nature of these relationships. This study examined if environment (marriage) or genetics (a single SNP, CHRNA5*rs16969968) would moderate the correlation of personality with CD, ND and cocaine-induced paranoia (CIP) in African and European Americans (AAs, EAs). 1432 EAs and 1513 AAs were examined using logistic regression. Personality was assessed by NEO-PI-R, while CD, ND and CIP were diagnosed according to DSM-IV. ND and CD were examined as binary traits and for the analysis of CIP, subjects were divided into 3 groups: (A) Controls with no CIP; (B) CD cases without CIP; and (C) CD cases with CIP. Multiple testing was Bonferroni-corrected. For CD and ND in the EA population, marital status proved to be a significant moderator in their relationship with openness only (OR = 1.90, 95%CI = 1.36–2.64, p = 1.54e-04 and OR = 2.12, 95%CI = 1.52–2.90, p = 4.65e-06 respectively). For CIP, marriage was observed to moderate its correlation with openness and neuroticism (OR = 1.39, 95%CI = 1.18–1.63, p = 7.64e-04 and OR = 1.26, 95%CI = 1.12–1.42, p = 1.27e-03 respectively). The correlations moderated by rs16969968 were those of conscientiousness and CD (OR = 1.62, 95%CI: 1.23–2.12, p = 8.94e-04) as well as CIP (OR = 1.21, 95%CI: 1.11–1.32, p = 4.93e-04 when comparing group A versus group C). No significant interactions were observed in AA population. The Bonferroni-corrected significance threshold was set to be 1.67e-03. The role of personality in CD and CIP may be interceded by both environment and genetics, while in ND by environment only.
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影响因子：
7.7
作者：
Freathy RM;Kazeem GR;Morris RW;Johnson PC;Paternoster L;Ebrahim S;Hattersley AT;Hill A;Hingorani AD;Holst C;Jefferis BJ;Kring SI;Mooser V;Padmanabhan S;Preisig M;Ring SM;Sattar N;Upton MN;Vollenweider P;Waeber G;Sørensen TI;Frayling TM;Watt G;Lawlor DA;Whincup PH;Tozzi F;Davey Smith G;Munafò M
通讯作者：
Munafò M
影响因子：
3.3
作者：
Donnellan, MB;Conger, RD;Bryant, CM
通讯作者：
Bryant, CM
影响因子：
4.2
作者：
Clemmey, P;Brooner, R;Stitzer, M
通讯作者：
Stitzer, M
影响因子：
3.3
作者：
Denissen, Jaap J. A.;Penke, Lars
通讯作者：
Penke, Lars
影响因子：
4
作者：
Brown, J. Scott;Meadows, Sarah O.;Elder, Glen H., Jr.
通讯作者：
Elder, Glen H., Jr.