miR-sc3, a Novel MicroRNA, Promotes Schwann Cell Proliferation and Migration by Targeting Astn1
miR-sc3, a Novel MicroRNA, Promotes Schwann Cell Proliferation and Migration by Targeting Astn1
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miR-sc3，一种新型 MicroRNA，通过靶向 Astn1 促进雪旺细胞增殖和迁移
DOI：
10.3727/096368916x690520
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发表时间：
2016-05
影响因子：
3.3
通讯作者：
Li, Shiying
中科院分区：
文献类型：
--
作者：
Gu, Yun;Liu, Jie;Gu, Xiaosong;Li, Shiying
microRNAs（miRNAs，miRs）是一类在转录后水平调控基因表达的小分子非编码RNA。我们之前通过Solexa测序在坐骨神经横断后的近端坐骨神经中鉴定了一组新的miRNAs，miR-sc 3是该组的成员。在这项研究中，我们的目的是研究miR-sc 3对雪旺细胞（SC）的表型调节的影响。miR-sc 3在坐骨神经切断后的损伤神经中呈高表达。miR-sc 3表达的增加和减少分别促进和减少原代SC的增殖和迁移。miR-sc 3直接靶向astrotactin 1（Astn 1）并导致Astn 1的翻译抑制。坐骨神经切断后，坐骨神经近端miR-sc 3和Astn 1的表达呈时间依赖性负相关。总之，miR-sc 3通过靶向Astn 1影响SC的增殖和迁移，从而在周围神经再生中发挥调节作用。
MicroRNAs (miRNAs, miRs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level. We have previously identified a group of novel miRNAs in proximal sciatic nerve after sciatic nerve transection by Solexa sequencing, and miR-sc3 is a member of the group. In this study, we aimed to investigate the effects of miR-sc3 on phenotypic modulation of Schwann cells (SCs). miR-sc3 was highly expressed in the injured nerve after sciatic nerve transection. An increased and decreased expression of miR-sc3 promoted and reduced the proliferation and migration of primary SCs, respectively. miR-sc3 directly targeted astrotactin 1 (Astn1) and led to translational suppression of Astn1. There was an inverse association between the time-dependent expressions of miR-sc3 and Astn1 in proximal sciatic nerve after sciatic nerve transection. Overall, miR-sc3 affected SC proliferation and migration by targeting Astn1, thus playing the regulatory role in peripheral nerve regeneration.
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DOI：
10.1080/14038190310012656
发表时间：
2003-01
期刊：
Advances in Physiotherapy
影响因子：
--
作者：
M. Landers;P. Altenburger
通讯作者：
M. Landers;P. Altenburger
DOI：
10.1002/ajmg.b.32048
发表时间：
2012-06
影响因子：
2.8
作者：
Hill, Shirley Y.;Weeks, Daniel E.;Jones, Bobby L.;Zezza, Nicholas;Stiffler, Scott
通讯作者：
Stiffler, Scott
影响因子：
4.6
作者：
N. Adams;T. Tomoda;M. Cooper;G. Dietz;M. Hatten
通讯作者：
N. Adams;T. Tomoda;M. Cooper;G. Dietz;M. Hatten
影响因子：
4
作者：
Bin Yu;Songlin Zhou;Yongjun Wang;Tianmei Qian;Guohui Ding;F. Ding;X. Gu
通讯作者：
Bin Yu;Songlin Zhou;Yongjun Wang;Tianmei Qian;Guohui Ding;F. Ding;X. Gu
影响因子：
5.3
作者：
Pereira, Jorge A.;Baumann, Reto;Suter, Ueli
通讯作者：
Suter, Ueli