Neonatal hypoxia, hippocampal atrophy, and memory impairment: evidence of a causal sequence.
Neonatal hypoxia, hippocampal atrophy, and memory impairment: evidence of a causal sequence.
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DOI：
10.1093/cercor/bht332
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Vargha-Khadem F
中科院分区：
文献类型：
--
作者：
Cooper JM;Gadian DG;Jentschke S;Goldman A;Munoz M;Pitts G;Banks T;Chong WK;Hoskote A;Deanfield J;Baldeweg T;de Haan M;Mishkin M;Vargha-Khadem F
治疗急性呼吸衰竭的新生儿会出现缺氧。海马体是记忆的基本结构，特别容易受到这种伤害。因此，一些接受急性呼吸衰竭治疗的新生儿可能会在生命早期出现双侧海马病理学，并在童年后期出现记忆问题。我们在一组40名因急性呼吸衰竭接受过外科治疗但无明显神经损伤的儿童中调查了这种可能性。该队列的平均海马体积（HV）显著低于正常对照值，记忆分数显著低于标准人群平均值，记忆力显著低于全量表智商预测值。脑白色物质的体积也低于对照组的体积，但脑灰质体积和非记忆神经心理学测试的分数在正常范围内。逐步线性回归模型显示，队列的HV可预测记忆障碍的程度，治疗时的胎龄可预测HV：年龄越小，萎缩越大。我们的结论是，许多新生儿治疗急性呼吸衰竭维持显着的海马萎缩，作为一个结果，相关的缺氧，因此，表现出记忆力不足，在以后的生活。
Neonates treated for acute respiratory failure experience episodes of hypoxia. The hippocampus, a structure essential for memory, is particularly vulnerable to such insults. Hence, some neonates undergoing treatment for acute respiratory failure might sustain bilateral hippocampal pathology early in life and memory problems later in childhood. We investigated this possibility in a cohort of 40 children who had been treated neonatally for acute respiratory failure but were free of overt neurological impairment. The cohort had mean hippocampal volumes (HVs) significantly below normal control values, memory scores significantly below the standard population means, and memory quotients significantly below those predicted by their full scale IQs. Brain white matter volume also fell below the volume of the controls, but brain gray matter volumes and scores on nonmnemonic neuropsychological tests were within the normal range. Stepwise linear regression models revealed that the cohort's HVs were predictive of degree of memory impairment, and gestational age at treatment was predictive of HVs: the younger the age, the greater the atrophy. We conclude that many neonates treated for acute respiratory failure sustain significant hippocampal atrophy as a result of the associated hypoxia and, consequently, show deficient memory later in life.
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影响因子：
15.9
作者：
de Haan, Michelle;Mishkin, Mortimer;Vargha-Khadem, Faraneh
通讯作者：
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影响因子：
2.2
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2.9
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3.7
作者：
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通讯作者：
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