A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia.
A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia.
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DOI：
10.1038/s41380-020-00901-5
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发表时间：
2021-07
影响因子：
11
通讯作者：
Sawa A
中科院分区：
文献类型：
--
作者：
Coughlin JM;Yang K;Marsman A;Pradhan S;Wang M;Ward RE;Bonekamp S;Ambinder EB;Higgs CP;Kim PK;Edwards JA;Varvaris M;Wang H;Posporelis S;Ma S;Tsujimura T;Edden RAE;Pomper MG;Sedlak TW;Fournier M;Schretlen DJ;Cascella NG;Barker PB;Sawa A
参与氧化应激精神分裂症（SZ）的病理生理学建议的外周组织的研究。尽管如此，目前还不清楚这些生物学变化如何与相关的病理性神经化学和大脑功能联系起来。我们设计了一个多方面的研究相结合的生物化学，神经影像学和神经心理学，以测试如何外周变化的一个关键标志物氧化应激，谷胱甘肽（GSH），可能与中枢神经化学物质或神经心理学表现在健康和SZ。使用MEGA-PRESS序列采集背侧前扣带皮层（dACC）中的GSH作为次级3 T 1H-MRS结果。对50名健康对照和46名SZ患者进行了横断面研究，并对混杂变量的影响进行了调整。我们观察到较低的外周总GSH SZ相比，控制细胞外（血浆）和细胞内（淋巴母细胞）池。血浆总GSH水平与整个人群和患者的复合神经心理学表现呈正相关。总血浆GSH水平也与整个人群以及每个单独组（对照组，患者）中dACC中Glx水平呈正相关。此外，dACC Glx和dACC GSH水平与患者组的综合神经心理学表现呈正相关。探索全身氧化应激（特别是GSH），中枢谷氨酸和认知之间的关系，在SZ将受益于更多样化的神经心理学表现的患者的评估进一步。
Involvement of oxidative stress in the pathophysiology of schizophrenia (SZ) is suggested by studies of peripheral tissue. Nonetheless, it is unclear how such biological changes are linked to relevant, pathological neurochemistry, and brain function. We designed a multi-faceted study by combining biochemistry, neuroimaging, and neuropsychology to test how peripheral changes in a key marker for oxidative stress, glutathione (GSH), may associate with central neurochemicals or neuropsychological performance in health and in SZ. GSH in dorsal anterior cingulate cortex (dACC) was acquired as a secondary 3T 1H-MRS outcome using a MEGA-PRESS sequence. Fifty healthy controls and 46 patients with SZ were studied cross-sectionally, and analyses were adjusted for effects of confounding variables. We observed lower peripheral total GSH in SZ compared to controls in extracellular (plasma) and intracellular (lymphoblast) pools. Total GSH levels in plasma positively correlated with composite neuropsychological performance across the total population and within patients. Total plasma GSH levels were also positively correlated with the levels of Glx in the dACC across the total population, as well as within each individual group (controls, patients). Furthermore, the levels of dACC Glx and dACC GSH positively correlated with composite neuropsychological performance in the patient group. Exploring the relationship between systemic oxidative stress (in particular GSH), central glutamate, and cognition in SZ will benefit further from assessment of patients with more varied neuropsychological performance.
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影响因子：
6.8
作者：
Lavoie S;Berger M;Schlögelhofer M;Schäfer MR;Rice S;Kim SW;Hesse J;McGorry PD;Smesny S;Amminger GP
通讯作者：
Amminger GP
影响因子：
10.6
作者：
Flatow, Joshua;Buckley, Peter;Miller, Brian J.
通讯作者：
Miller, Brian J.
影响因子：
11
作者：
Landek-Salgado MA;Faust TE;Sawa A
通讯作者：
Sawa A
影响因子：
6.9
作者：
Emiliani FE;Sedlak TW;Sawa A
通讯作者：
Sawa A
影响因子：
6.6
作者：
Marsman, Anouk;van den Heuvel, Martijn P.;Pol, Hilleke E. Hulshoff
通讯作者：
Pol, Hilleke E. Hulshoff