Meta-analysis of oxidative stress in schizophrenia.
Meta-analysis of oxidative stress in schizophrenia.
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DOI：
10.1016/j.biopsych.2013.03.018
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发表时间：
2013-09-15
影响因子：
10.6
通讯作者：
Miller, Brian J.
中科院分区：
文献类型：
--
作者：
Flatow, Joshua;Buckley, Peter;Miller, Brian J.
精神分裂症与抗氧化防御受损有关，包括血清、血浆和红细胞（RBC）氧化应激参数异常。我们对这些关联进行了荟萃分析，考虑了精神病急性加重后临床状态和抗精神病药物治疗的影响。我们通过检索PubMed、PsychInfo和Institute for Scientific Information以及已识别研究的参考文献列表来识别文章。44项研究符合纳入标准。总抗氧化状态似乎是一个状态标志物，因为在首次发作精神病（FEP）的血清和血浆的横断面研究中，总抗氧化状态水平显著降低，而在精神病急性加重的抗精神病药物治疗的纵向研究中，总抗氧化状态水平显著升高（每项研究p <0.01）。红细胞过氧化氢酶和血浆亚硝酸盐似乎是状态相关的标志物，因为在横断面研究中，FEP患者的水平显著降低（p <0.01），而稳定的门诊患者的水平显著升高（p = 0.01）。相比之下，RBC超氧化物歧化酶似乎是精神分裂症的一个特征标志物，因为在横断面研究中，急性复发住院患者、FEP和稳定门诊患者的RBC超氧化物歧化酶水平显著降低（每个患者p <0.01）。FEP中的氧化应激异常提示一种可能独立于抗精神病药物的效应。虽然一些参数（总抗氧化状态，红细胞过氧化氢酶，血浆亚硝酸盐）可能是精神病急性加重的状态标志物，其他（红细胞超氧化物歧化酶）可能是性状标志物，但是，需要更多的纵向研究。我们的研究结果表明，氧化应激可能作为一个潜在的生物标志物在精神分裂症的病因病理生理和临床过程。
Schizophrenia is associated with impaired antioxidant defense, including abnormal serum, plasma, and red blood cell (RBC) oxidative stress parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment after an acute exacerbation of psychosis. We identified articles by searching PubMed, PsychInfo, and Institute for Scientific Information, and the reference lists of identified studies. Forty-four studies met the inclusion criteria. Total antioxidant status seemed to be a state marker, because levels were significantly decreased in cross-sectional studies of serum and plasma in first-episode psychosis (FEP) and significantly increased in longitudinal studies of antipsychotic treatment for acute exacerbations of psychosis (p < .01 for each). The RBC catalase and plasma nitrite seemed to be state-related markers, because levels in cross-sectional studies were significantly decreased in FEP (p < .01) and significantly increased in stable outpatients (p = .01). In contrast, RBC superoxide dismutase seemed to be a trait marker for schizophrenia, because levels in cross-sectional studies were significantly decreased in acutely relapsed inpatients, FEP, and stable outpatients (p < .01 for each). Oxidative stress abnormalities in FEP suggest an effect that might be independent of antipsychotic medications. Although some parameters (total antioxidant status, RBC catalase, and plasma nitrite) might be state markers for acute exacerbations of psychosis, others (RBC superoxide dismutase) might be trait markers; however, more longitudinal studies are needed. Our findings suggest that oxidative stress might serve as a potential biomarker in the etiopathophysiology and clinical course of schizophrenia.
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影响因子：
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通讯作者：
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