Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice.
Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice.
复制标题
DOI：
10.1016/j.reprotox.2016.07.020
复制
发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Greenberg AS
中科院分区：
文献类型：
--
作者：
Rubin BS;Paranjpe M;DaFonte T;Schaeberle C;Soto AM;Obin M;Greenberg AS
在围产期或围产期和青春期周围暴露于0、0.25、2.5、25或250 μg BPA/kg BW/天的CD-1小鼠中检查体重（BW）和身体组成。我们的目标是确定增加体重和肥胖的BPA剂量和暴露窗口，并评估这种反应的潜在性别差异。无论是围产期暴露单独和围产期加上青春期暴露于环境相关水平的BPA导致持久的影响体重和身体成分。这些效应具有剂量特异性和性别特异性，并受到BPA暴露的精确窗口的影响。在围产期暴露后增加围青春期BPA暴露加剧了女性的不良反应，但似乎减少了对照组和BPA暴露组男性之间体重和身体成分的差异。BPA对体重和体成分的影响呈非线性剂量反应。
Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250 μg BPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure. The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males. Some effects of BPA on body weight and body composition showed a non-linear dose response.
登录
查看更多内容
影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
DOI：
10.1016/j.reprotox.2013.07.017
发表时间：
2013-12
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Angle BM;Do RP;Ponzi D;Stahlhut RW;Drury BE;Nagel SC;Welshons WV;Besch-Williford CL;Palanza P;Parmigiani S;vom Saal FS;Taylor JA
通讯作者：
Taylor JA
影响因子：
10.4
作者：
Alonso-Magdalena P;Vieira E;Soriano S;Menes L;Burks D;Quesada I;Nadal A
通讯作者：
Nadal A
影响因子：
4.8
作者：
Alonso-Magdalena, Paloma;Garcia-Arevalo, Marta;Nadal, Angel
通讯作者：
Nadal, Angel
影响因子：
4.1
作者：
Grün F;Blumberg B
通讯作者：
Blumberg B