Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering.
Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering.
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DOI：
10.1260/2040-2295.3.2.179
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发表时间：
2012-06
影响因子：
--
通讯作者：
Liao J
中科院分区：
文献类型：
--
作者：
Simionescu DT;Chen J;Jaeggli M;Wang B;Liao J
由于天然主动脉心脏瓣膜中存在的特定血液动力学和生物学条件，组织工程化主动脉心脏瓣膜是一项具有挑战性的奋进。理想的瓣膜替代品的支柱应该是一个支架，它足够坚固，可以承受数十亿次重复的弯曲，弯曲和拉伸循环，同时也可以缓慢降解，以允许重塑。在这篇综述中，我们强调了三个被忽视的方面，可能会影响组织工程瓣膜的长期耐用性：复制天然瓣膜三层组织结构，复制瓣膜的三维形状和细胞整合的努力集中在获得正确的数量和类型的细胞到正确的位置内的瓣膜结构，并推动他们对瓣膜基质的稳态维持。我们建议，在天然主动脉瓣的三层结构，其中包括一个中间海绵层缓冲的两个外部纤维层的运动应该是我们的模板，用于创建新的支架具有改善的机械耐久性。此外，由于细胞适应瓣膜结构内的微负荷，我们认为瓣膜基质的间质细胞重塑将取决于结构和负荷的准确复制，从而导致瓣膜组织的成功再生和延长的耐久性。
Tissue engineering the aortic heart valve is a challenging endeavor because of the particular hemodynamic and biologic conditions present in the native aortic heart valve. The backbone of an ideal valve substitute should be a scaffold that is strong enough to withstand billions of repetitive bending, flexing and stretching cycles, while also being slowly degradable to allow for remodeling. In this review we highlight three overlooked aspects that might influence the long term durability of tissue engineered valves: replication of the native valve trilayered histoarchitecture, duplication of the three-dimensional shape of the valve and cell integration efforts focused on getting the right number and type of cells to the right place within the valve structure and driving them towards homeostatic maintenance of the valve matrix. We propose that the trilayered structure in the native aortic valve that includes a middle spongiosa layer cushioning the motions of the two external fibrous layers should be our template for creation of novel scaffolds with improved mechanical durability. Furthermore, since cells adapt to micro-loads within the valve structure, we believe that interstitial cell remodeling of the valvular matrix will depend on the accurate replication of the structures and loads, resulting in successful regeneration of the valve tissue and extended durability.
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影响因子：
1.7
作者：
Del Gaudio, C.;Grigioni, M.;De Angelis, G.
通讯作者：
De Angelis, G.
影响因子：
6.1
作者：
Fang Ning-tao;Xie Shang-zhe;Pan Luan-feng
通讯作者：
Pan Luan-feng
影响因子：
4.6
作者：
da Costa, Francisco D. A.;Costa, Ana Claudia B. A.;Lopes, Sergio Veiga
通讯作者：
Lopes, Sergio Veiga
影响因子：
--
作者：
Dvorin, EL;Wylie-Sears, J;Bischoff, J
通讯作者：
Bischoff, J
影响因子：
2.9
作者：
Bowlin, GL;Meyer, A;Rittgers, SE
通讯作者：
Rittgers, SE