Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children.
Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children.
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DOI：
10.3389/fpsyt.2021.816196
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发表时间：
2021
影响因子：
4.7
通讯作者：
Tsuchiya KJ
中科院分区：
文献类型：
--
作者：
Iwabuchi T;Takahashi N;Nishimura T;Rahman MS;Harada T;Okumura A;Kuwabara H;Takagai S;Nomura Y;Matsuzaki H;Ozaki N;Tsuchiya KJ
越来越多的证据表明，母亲的代谢状况，如孕前超重，糖尿病和妊娠高血压疾病（HDP）是自闭症谱系障碍（ASD）的潜在危险因素。然而，目前尚不清楚这些母体条件如何导致后代的神经发育结果，包括自闭症症状。瘦素是一种具有促炎作用并影响胎儿神经发育的脂肪因子，是母体代谢因素与ASD风险增加之间关联的候选介质。然而，产前暴露于瘦素是否介导母亲代谢状况和儿童自闭症症状之间的关联尚未调查。本研究采用广义结构方程模型，调查了母亲的代谢状况（孕前超重、孕期或孕前糖尿病和HDP）、脐带血清中的瘦素浓度与762名儿童自闭症症状之间的关系。我们在8-9岁时使用社会反应量表第二版（SRS-2）计算总T评分。此外，我们还使用了两个子域的T分数：社会沟通和互动（SCI）和限制性兴趣和重复行为（RRB）。脐带瘦素水平与孕前超重[系数= 1.297，95%可信区间（CI）1.081-1.556，p = 0.005]和糖尿病（系数= 1.574，95% CI 1.206-2.055，p = 0.001）相关。此外，瘦素水平与SRS-2总T评分显著相关（系数= 1.002，95% CI 1.000-1.004，p = 0.023），SCI评分（系数= 1.002，95% CI 1.000-1.004，p = 0.020）和RRB评分（系数= 1.001，95% CI 1.000-1.003，p = 0.044）。母亲的代谢因素和自闭症症状之间的关联并不显着。本研究揭示了脐带瘦素水平与儿童自闭症症状之间的关联，而母亲的代谢状况对结果没有明显的直接影响。这些结果表明，产前促炎环境受母体代谢条件的影响，可能有助于儿童自闭症症状的发展。这些发现证明了瘦素在自闭症症状发展中的作用的进一步研究。
Accumulating evidence has shown that maternal metabolic conditions, such as pre-pregnancy overweight, diabetes mellitus, and hypertensive disorders of pregnancy (HDP) are potential risk factors of autism spectrum disorder (ASD). However, it remains unclear how these maternal conditions lead to neurodevelopmental outcomes in the offspring, including autistic symptoms. Leptin, an adipokine that has pro-inflammatory effects and affects fetal neurodevelopment, is a candidate mediator of the association between maternal metabolic factors and an increased risk of ASD. However, whether prenatal exposure to leptin mediates the association between maternal metabolic conditions and autistic symptoms in children has not been investigated yet. This study investigated the associations between mothers' metabolic conditions (pre-pregnancy overweight, diabetes mellitus during or before pregnancy, and HDP), leptin concentrations in umbilical cord serum, and autistic symptoms among 762 children from an ongoing cohort study, using generalized structural equation modeling. We used the Social Responsive Scale, Second Edition (SRS-2) at 8–9 years old to calculate total T-scores. Additionally, we used the T-scores for two subdomains: Social Communication and Interaction (SCI) and Restricted Interests and Repetitive Behavior (RRB). Umbilical cord leptin levels were associated with pre-pregnancy overweight [coefficient = 1.297, 95% confidence interval (CI) 1.081–1.556, p = 0.005] and diabetes mellitus (coefficient = 1.574, 95% CI 1.206–2.055, p = 0.001). Furthermore, leptin levels were significantly associated with SRS-2 total T-scores (coefficient = 1.002, 95% CI 1.000–1.004, p = 0.023), SCI scores (coefficient = 1.002, 95% CI 1.000–1.004, p = 0.020), and RRB scores (coefficient = 1.001, 95% CI 1.000–1.003, p = 0.044) in children. Associations between maternal metabolic factors and autistic symptoms were not significant. The present study uncovered an association between cord leptin levels and autistic symptoms in children, while maternal metabolic conditions did not have an evident direct influence on the outcome. These results imply that prenatal pro-inflammatory environments affected by maternal metabolic conditions may contribute to the development of autistic symptoms in children. The findings warrant further investigation into the role of leptin in the development of autistic symptoms.
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影响因子：
7.7
作者：
Dumon C;Diabira D;Chudotvorova I;Bader F;Sahin S;Zhang J;Porcher C;Wayman G;Medina I;Gaiarsa JL
通讯作者：
Gaiarsa JL
影响因子：
3.4
作者：
Aydin, S.;Guzel, S. P.;Halifeoglu, I.
通讯作者：
Halifeoglu, I.
DOI：
10.1093/cercor/bhaa381
发表时间：
2021-03-31
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Gharehgazlou A;Freitas C;Ameis SH;Taylor MJ;Lerch JP;Radua J;Anagnostou E
通讯作者：
Anagnostou E
母体糖尿病与神经发育障碍的关联：自闭症谱系障碍，注意力缺陷/多动障碍和智力障碍。
影响因子：
7.7
作者：
Chen S;Zhao S;Dalman C;Karlsson H;Gardner R
通讯作者：
Gardner R
影响因子：
4.6
作者：
Al-Zaid FS;Alhader AA;Al-Ayadhi LY
通讯作者：
Al-Ayadhi LY