Altered ghrelin levels in boys with autism: a novel finding associated with hormonal dysregulation.
Altered ghrelin levels in boys with autism: a novel finding associated with hormonal dysregulation.
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DOI：
10.1038/srep06478
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发表时间：
2014-09-26
影响因子：
4.6
通讯作者：
Al-Ayadhi LY
中科院分区：
文献类型：
--
作者：
Al-Zaid FS;Alhader AA;Al-Ayadhi LY
孤独症是一种神经发育障碍性疾病，其发病机制尚不清楚。许多临床观察和激素研究表明，自闭症与神经保护激素ghrelin有关。目前的研究旨在调查ghrelin在自闭症中的潜在作用，并阐明相关的激素失调。本病例对照研究调查了31名男性自闭症儿童和28名年龄和性别匹配的健康对照组的酰基ghrelin（AG）、去酰基ghrelin（DG）、总睾酮（TT）、游离睾酮（FT）、瘦素和生长激素（GH）水平。使用酶联免疫吸附试验和化学发光免疫分析试剂盒测量血液中的激素水平。自闭症组的AG、DG和GH水平显著低于对照组（分别为p ≤ 0.001、p ≤ 0.005和p ≤ 0.05）。然而，自闭症组的TT、FT和瘦素水平明显高于对照组（分别为p ≤ 0.05、p ≤ 0.001和p ≤ 0.01）。我们的研究结果第一次证明自闭症儿童的AG和DG水平较低。考虑到生长激素释放肽影响与自闭症相关的神经炎症和凋亡过程的能力，这项研究表明生长激素释放肽在自闭症发病机制中的潜在作用。
Autism is a neurodevelopmental disorder with unclear pathogenesis. Many clinical observations and hormone studies have suggested the involvement of the neuroprotective hormone ghrelin in autism. The current study aimed to investigate the potential role of ghrelin in autism and to elucidate the associated hormonal dysregulation. This case-control study investigated acyl ghrelin (AG), des-acyl ghrelin (DG), total testosterone (TT), free testosterone (FT), leptin and growth hormone (GH) levels in 31 male children with autism and 28 healthy age and sex-matched controls. Hormone levels were measured in the blood using enzyme-linked immunosorbent assay and chemiluminescence immunoassay kits. AG, DG and GH levels were significantly lower in the autism group than in the control group (p ≤ 0.001, p ≤ 0.005 and p ≤ 0.05, respectively). However, TT, FT and leptin levels were significantly higher in the autism group than in the control group (p ≤ 0.05, p ≤ 0.001 and p ≤ 0.01, respectively). Our results for the first time demonstrate low AG and DG levels in autistic children. Considering the capacity of ghrelin to affect neuroinflammatory and apoptotic processes that are linked to autism, this study suggests a potential role for the hormone ghrelin in the pathogenesis of autism.
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DOI：
10.1152/ajpcell.1998.274.6.c1645
发表时间：
1998-06-01
影响因子：
5.5
作者：
Dieudonné, MN;Pecquery, R;Giudicelli, Y
通讯作者：
Giudicelli, Y
影响因子：
5.8
作者：
Lebenthal, Y;Gat-Yablonski, G;Lazar, L
通讯作者：
Lazar, L
影响因子：
5.2
作者：
MOORTHY, B;PAPADOPOLOU, M;GRANT, DB
通讯作者：
GRANT, DB
影响因子：
5.8
作者：
Kriström, B;Carlsson, B;Albertsson-Wikland, K
通讯作者：
Albertsson-Wikland, K
影响因子：
5.8
作者：
Caminos, JE;Seoane, LM;Dieguez, C
通讯作者：
Dieguez, C