Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.
Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.
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DOI：
10.1093/cercor/bhaa381
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发表时间：
2021-03-31
期刊：
影响因子：
--
通讯作者：
Anagnostou E
中科院分区：
文献类型：
--
作者：
Gharehgazlou A;Freitas C;Ameis SH;Taylor MJ;Lerch JP;Radua J;Anagnostou E
自闭症谱系障碍(ASD)和注意力缺陷多动障碍(ADHD)是常见的神经发育障碍(NDDS)，可能会影响大脑成熟。许多研究都检查了这两个NDD的皮质回变形态。在这里，我们回顾并在可能的情况下汇集他们的结果，以更好地理解共享的和潜在的障碍特有的回旋特征。我们检索了MEDLINE、CogcINFO和EMBASE数据库，分别有24项和10项研究符合纳入系统综述和荟萃分析部分的标准。使用SDM软件对ASD研究中的局部旋转指数(LGI)结果进行Meta分析，该软件适用于基于表面的形态测量研究。运用元回归分析探讨年龄、性别和样本量对脑回旋差异的影响。不同组之间的旋转没有显著差异。对其余ASD研究的定性综合突出了结果的异质性。大规模的ADHD研究表明，与ASD相似，病例和对照组之间的回旋没有差异，目前没有证据表明与对照组相比，回旋的形态存在差异。需要进行更大规模的纵向研究，以进一步阐明年龄、性别和智商对这些NDD患者皮质回变的影响。
Autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are common neurodevelopmental disorders (NDDs) that may impact brain maturation. A number of studies have examined cortical gyrification morphology in both NDDs. Here we review and when possible pool their results to better understand the shared and potentially disorder-specific gyrification features. We searched MEDLINE, PsycINFO, and EMBASE databases, and 24 and 10 studies met the criteria to be included in the systematic review and meta-analysis portions, respectively. Meta-analysis of local Gyrification Index (lGI) findings across ASD studies was conducted with SDM software adapted for surface-based morphometry studies. Meta-regressions were used to explore effects of age, sex, and sample size on gyrification differences. There were no significant differences in gyrification across groups. Qualitative synthesis of remaining ASD studies highlighted heterogeneity in findings. Large-scale ADHD studies reported no differences in gyrification between cases and controls suggesting that, similar to ASD, there is currently no evidence of differences in gyrification morphology compared with controls. Larger, longitudinal studies are needed to further clarify the effects of age, sex, and IQ on cortical gyrification in these NDDs.
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5.7
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