Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis.
Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis.
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DOI：
10.1136/sti.2009.040592
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发表时间：
2010-08
影响因子：
3.6
通讯作者：
Zenilman JM
中科院分区：
文献类型：
--
作者：
Brotman RM;Ravel J;Cone RA;Zenilman JM
细菌性阴道病（BV）的病因尚不清楚。我们试图描述阴道微生物群的纵向变化。39名妇女每周两次自行收集阴道标本，为期16周，作为阴道灌洗停止研究的一部分。在每个女性作为自己对照的分析中，我们使用条件逻辑回归来评估与女性BV事件相关的日常时变因素，并将其与持续BV阴性样本进行比较。以纽金特革兰氏染色评分≥7来定义BV。平均年龄36.8岁；56.4%是非裔美国人。46.2%的参与者在前四周的观察中出现了细菌性阴道炎。226例转入细菌性阴道炎或自行缓解的患者阴道菌群出现快速波动。BV的持续时间通常很短：51%的发作只持续一个样本间隔（三天）。在至少有一次BV发作的女性中，每位女性发作的中位数为8.7次（SD=7.4，范围：1-22）。在标本采集前一天使用润滑剂（调整优势比（aOR）： 11.75, 95%可信区间（CI）： 1.96-70.27）和两天前的直肠性行为（aOR: 4.48, 95% CI: 2.79-7.17）与BV发病相关。观察到阴道微生物群的快速波动。抽样间隔时间长的纵向研究很可能会错过BV的发作。最近的报告显示，使用润滑剂和直肠性行为与BV事件有关。
The etiology of bacterial vaginosis (BV) remains unknown. We sought to describe longitudinal changes in vaginal microbiota. Thirty-nine women self-collected vaginal specimens twice-weekly for 16 weeks as part of a vaginal douching cessation study. In an analysis where each woman serves as her own control, we used Conditional Logistic Regression to evaluate daily, time-varying factors associated with a woman’s incident BV episode(s) as compared to her persistently BV-negative sample(s). BV was defined by Nugent’s Gram stain score ≥7. The mean age was 36.8 years; 56.4% were African-American. 46.2% of participants had BV in the first four weeks of observation. Rapid fluctuation of vaginal microbiota was observed in 226 transitions to BV or spontaneous remission. Duration of BV was often short: 51% of the episodes lasted only one sample interval (three days). Among women who had at least one BV episode, the median number of episodes per woman was 8.7 (SD=7.4, range: 1–22). Lubricant use one day prior to specimen collection (adjusted odds ratio (aOR): 11.75, 95% confidence interval (CI): 1.96–70.27) and rectal sex two days prior (aOR: 4.48, 95% CI: 2.79–7.17) were associated with BV onset. Rapid fluctuation of the vaginal microbiota was observed. Longitudinal studies with long intervals between sampling are likely to miss episodes of BV. Recent report of lubricant use and rectal sex were associated with incident BV.
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影响因子：
9.8
作者：
Nansel, TR;Riggs, MA;Klebanoff, MA
通讯作者：
Klebanoff, MA
影响因子：
158.5
作者：
Hillier, SL;Nugent, RP;Klebanoff, MA
通讯作者：
Klebanoff, MA
影响因子：
11.8
作者：
Eschenbach, DA;Thwin, SS;Stamm, WE
通讯作者：
Stamm, WE
影响因子：
11.8
作者：
Cherpes, TL;Meyn, LA;Hillier, SL
通讯作者：
Hillier, SL
影响因子：
3.1
作者：
Cherpes, Thomas L.;Hillier, Sharon L.;Krohn, Marijane A.
通讯作者：
Krohn, Marijane A.