A Comparison of Etiology, Pathogenesis, Vaccinal and Antiviral Drug Development between Influenza and COVID-19.

A Comparison of Etiology, Pathogenesis, Vaccinal and Antiviral Drug Development between Influenza and COVID-19.
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DOI:
10.3390/ijms24076369
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发表时间:
2023-03-28
影响因子:
5.6
通讯作者:
Gao, Rongbao
Gao, Rongbao
中科院分区:
生物学2区
文献类型:
--
作者:
Luo, Junhao;Zhang, Zhuohan;Zhao, Song;Gao, Rongbao

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流感病毒和冠状病毒是自然界中广泛存在的两种病原体,是引起人类呼吸道感染的常见新兴病原体。于二零一九年十二月,一种新型冠状病毒SARS-CoV-2出现,导致人类严重呼吸道感染,名为COVID-19,并引发全球大流行,已在全球持续近三年。流感病毒是一种季节性传播的呼吸道病原体,自1918年以来,由于出现了新的变异体,已经在人类中引起了四次全球大流行。研究表明,流感和COVID-19在传播方式和发病机制上有一定的相似性,疫苗接种和抗病毒药物被认为在预防和控制两种疾病方面具有积极作用,但也存在一些局限性。对这些疾病的比较了解有助于疾病的预防和控制。本文就这两种疾病的病因、发病机制、疫苗和抗病毒药物的研究进展作一综述。
Influenza virus and coronavirus, two kinds of pathogens that exist widely in nature, are common emerging pathogens that cause respiratory tract infections in humans. In December 2019, a novel coronavirus SARS-CoV-2 emerged, causing a severe respiratory infection named COVID-19 in humans, and raising a global pandemic which has persisted in the world for almost three years. Influenza virus, a seasonally circulating respiratory pathogen, has caused four global pandemics in humans since 1918 by the emergence of novel variants. Studies have shown that there are certain similarities in transmission mode and pathogenesis between influenza and COVID-19, and vaccination and antiviral drugs are considered to have positive roles as well as several limitations in the prevention and control of both diseases. Comparative understandings would be helpful to the prevention and control of these diseases. Here, we review the study progress in the etiology, pathogenesis, vaccine and antiviral drug development for the two diseases.
DOI: 10.1007/s10096-020-04138-6
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