Effect of COVID-19 vaccination on the timing and flow of menstrual periods in two cohorts.
Effect of COVID-19 vaccination on the timing and flow of menstrual periods in two cohorts.
复制标题
COVID-19疫苗接种对两个队列中月经期的时间和流动的影响。
DOI：
10.3389/frph.2022.952976
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发表时间：
2022
影响因子：
--
通讯作者：
Male, Victoria
中科院分区：
文献类型：
--
作者：
Alvergne, Alexandra;Woon, Ee Von;Male, Victoria
COVID-19 疫苗接种可以预防 SARS-CoV-2 感染的潜在严重后果，但有些人对接种疫苗犹豫不决，因为有报道称它可能会影响月经出血。为了确定这种情况是否会发生，我们前瞻性地招募了 79 人组成的队列，每个人都记录了至少三个连续月经周期的详细信息，在此期间他们每个人都至少接种了一剂 COVID-19 疫苗。在自发骑自行车的参与者中，COVID-19 疫苗接种与下一周期的延迟有关，但这种变化在随后的未接种疫苗的周期中逆转。服用激素避孕的人没有发现延迟。为了探索有关这些月经变化发生机制的假设，我们回顾性地招募了一个更大的队列，其中有 1,273 名记录了月经周期和疫苗接种日期的人。在这个队列中，我们发现使用联合激素避孕药的趋势可以防止月经延迟，这表明疫苗接种后的月经变化可能是由卵巢激素的扰动介导的。然而，我们无法发现月经周期内的疫苗接种时间与月经变化报告之间存在明确的关联。我们的研究结果表明，COVID-19 疫苗接种可以延长月经周期，并且这种效应可能是由卵巢激素介导的。重要的是，我们发现在未接种疫苗的周期中，月经周期会恢复到接种疫苗前的长度。
COVID-19 vaccination protects against the potentially serious consequences of SARS-CoV-2 infection, but some people have been hesitant to receive the vaccine because of reports that it could affect menstrual bleeding. To determine whether this occurs we prospectively recruited a cohort of 79 individuals, each of whom recorded details of at least three consecutive menstrual cycles, during which time they each received at least one dose of COVID-19 vaccine. In spontaneously cycling participants, COVID-19 vaccination was associated with a delay to the next period, but this change reversed in subsequent unvaccinated cycles. No delay was detected in those taking hormonal contraception. To explore hypotheses about the mechanism by which these menstrual changes occur, we retrospectively recruited a larger cohort, of 1,273 people who had kept a record of their menstrual cycle and vaccination dates. In this cohort, we found a trend toward use of combined hormonal contraception being protective against reporting a delayed period, suggesting that menstrual changes following vaccination may be mediated by perturbations to ovarian hormones. However, we were unable to detect a clear association between the timing of vaccination within the menstrual cycle and reports of menstrual changes. Our findings suggest that COVID-19 vaccination can lengthen the menstrual cycle and that this effect may be mediated by ovarian hormones. Importantly, we find that the menstrual cycle returns to its pre-vaccination length in unvaccinated cycles.
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影响因子：
4.6
作者：
Malchrzak W;Mastalerz-Migas A;Sroka Z;Spiegel M
通讯作者：
Spiegel M
影响因子：
6.1
作者：
Bentov, Y.;Beharier, O.;Klement, A. Hersko
通讯作者：
Klement, A. Hersko
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1038/s41577-021-00525-y
发表时间：
2021-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Male V
通讯作者：
Male V
DOI：
10.1038/s41577-021-00526-x
发表时间：
2021-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Teijaro JR;Farber DL
通讯作者：
Farber DL