Deep learning-based model for diagnosing Alzheimer's disease and tauopathies.
Deep learning-based model for diagnosing Alzheimer's disease and tauopathies.
复制标题
基于深度学习的阿尔茨海默病和tau蛋白病诊断模型。
DOI：
10.1111/nan.12759
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发表时间：
2022-03
影响因子：
5
通讯作者：
Dickson, Dennis W.
中科院分区：
文献类型：
--
作者：
Koga, Shunsuke;Ikeda, Akihiro;Dickson, Dennis W.
关键词：
This study aimed to develop a deep learning‐based model for differentiating tauopathies, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and Pick's disease (PiD), based on tau‐immunostained digital slide images. We trained the YOLOv3 object detection algorithm to detect five tau lesion types: neuronal inclusions, neuritic plaques, tufted astrocytes, astrocytic plaques and coiled bodies. We used 2522 digital slide images of CP13‐immunostained slides of the motor cortex from 10 cases each of AD, PSP and CBD for training. Data augmentation was performed to increase the size of the training dataset. We next constructed random forest classifiers using the quantitative burdens of each tau lesion from motor cortex, caudate nucleus and superior frontal gyrus, ascertained from the object detection model. We split 120 cases (32 AD, 36 PSP, 31 CBD and 21 PiD) into training (90 cases) and test (30 cases) sets to train random forest classifiers. The resultant random forest classifier achieved an average test score of 0.97, indicating that 29 out of 30 cases were correctly diagnosed. A validation study using hold‐out datasets of CP13‐ and AT8‐stained slides from 50 cases (10 AD, 17 PSP, 13 CBD and 10 PiD) showed >92% (without data augmentation) and >95% (with data augmentation) diagnostic accuracy in both CP13‐ and AT8‐stained slides. Our diagnostic model trained with CP13 also works for AT8; therefore, our diagnostic tool can be potentially used by other investigators and may assist medical decision‐making in neuropathological diagnoses of tauopathies. We developed a deep learning‐based tool for diagnosing Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and Pick’s disease (PiD), based on tau‐immunostained digital slide images. Combining an object detection model that could recognize and count five tau lesion types and a random forest classifier could successfully differentiate four tauopathies. A validation study using hold‐out datasets of CP13‐ and AT8‐stained slides from 50 cases showed >95% diagnostic accuracy in both CP13‐ and AT8‐stained slides.
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影响因子：
5
作者：
Koga, Shunsuke;Zhou, Xiaolai;Dickson, Dennis W.
通讯作者：
Dickson, Dennis W.
DOI：
10.1007/s12031-011-9589-0
发表时间：
2011-11
期刊：
Journal of molecular neuroscience : MN
影响因子：
--
作者：
Dickson DW;Kouri N;Murray ME;Josephs KA
通讯作者：
Josephs KA
影响因子：
6
作者：
Komura D;Ishikawa S
通讯作者：
Ishikawa S
影响因子：
12.7
作者：
Ahmed, Zeshan;Bigio, Eileen H.;Kovacs, Gabor G.
通讯作者：
Kovacs, Gabor G.
影响因子：
12.7
作者：
Kovacs, Gabor G.;Lukic, Milica Jecmenica;Hoeglinger, Guenter U.
通讯作者：
Hoeglinger, Guenter U.