Circulating bile acids concentration is predictive of coronary artery disease in human.
Circulating bile acids concentration is predictive of coronary artery disease in human.
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DOI：
10.1038/s41598-021-02144-y
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发表时间：
2021-11-22
影响因子：
4.6
通讯作者：
Duboc H
中科院分区：
文献类型：
--
作者：
Chong Nguyen C;Duboc D;Rainteau D;Sokol H;Humbert L;Seksik P;Bellino A;Abdoul H;Bouazza N;Treluyer JM;Saadi M;Wahbi K;Soliman H;Coffin B;Bado A;Le Gall M;Varenne O;Duboc H
BA由肝脏合成，由肠道微生物区系代谢，参与与心血管疾病相关的代谢性肝病。动脉粥样硬化的动物模型证明胆汁酸(BA)具有强大的抗动脉粥样硬化作用。这项前瞻性研究调查了循环中BA的变化是否可以预测人类的冠状动脉疾病(CAD)。连续接受冠状动脉造影术的患者入选。用高压液相色谱和串联质谱仪测定循环和粪便中的BA。在筛选的406名患者中，80名前瞻性纳入并分为两组：有冠心病(n = 45例)和无冠心病(n = 35例)。冠心病组和非冠心病组的血清总BA平均浓度分别为对照组的两倍(P = 0.005)。经性别和年龄调整后，这种下降是冠心病的独立预测因素。在17名患者的亚组中，他汀类药物治疗使血清BA浓度增加了一倍。血清BA浓度降低是人类冠心病的预测因子。亚组分析显示他汀类药物可能进行了校正。关于BA在动物模型中的抗动脉粥样硬化作用及其在人类脂代谢中的作用，本研究描述了一种与人类CAD相关的新的代谢紊乱。
Synthetized by the liver and metabolized by the gut microbiota, BA are involved in metabolic liver diseases that are associated with cardiovascular disorders. Animal models of atheroma documented a powerful anti-atherosclerotic effect of bile acids (BA). This prospective study examined whether variations in circulating BA are predictive of coronary artery disease (CAD) in human. Consecutive patients undergoing coronary angiography were enrolled. Circulating and fecal BA were measured by high pressure liquid chromatography and tandem mass spectrometry. Of 406 screened patients, 80 were prospectively included and divided in two groups with (n = 45) and without (n = 35) CAD. The mean serum concentration of total BA was twice lower in patients with, versus without CAD (P = 0.005). Adjusted for gender and age, this decrease was an independent predictor of CAD. In a subgroup of 17 patients, statin therapy doubled the serum BA concentration. Decreased serum concentrations of BA were predictors of CAD in humans. A subgroup analysis showed a possible correction by statins. With respect to the anti-atherosclerotic effect of BA in animal models, and their role in human lipid metabolism, this study describe a new metabolic disturbance associated to CAD in human.
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