Raised without a father: monoparental care effects over development, sexual behavior, sexual reward, and pair bonding in prairie voles.
Raised without a father: monoparental care effects over development, sexual behavior, sexual reward, and pair bonding in prairie voles.
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没有父亲抚养长大：单亲照料对草原田鼠的发育、性行为、性奖励和配对关系的影响。
DOI：
10.1016/j.bbr.2021.113264
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发表时间：
2021-06-25
影响因子：
2.7
通讯作者：
Portillo W
中科院分区：
文献类型：
--
作者：
Valera-Marín G;Young LJ;Camacho F;Paredes RG;Rodríguez VM;Díaz NF;Portillo W
大约5%的哺乳动物是社会性的一夫一妻制，父母双方都照顾幼崽（双亲，BP）。草原田鼠是一夫一妻制的啮齿类动物，广泛用于了解配对关系形成的神经生物学基础以及父母一方缺席对后代的影响。配对结合，其特征是选择性地与性伴侣联系，在草原田鼠中，通过交配6小时或同居24小时而不交配来促进。以前的研究表明，由母亲单独抚养的草原田鼠（单亲，MP）在成年后表现出延迟的配对键形成。在这项研究中，我们评估了BP和MP护理对后代发育的影响，检测嗅觉线索的能力，对性相关气味的偏好，性行为的表现，以及交配的奖励效果。我们还测量了多巴胺和5-羟色胺的浓度，在核腹侧纹状体（腹侧纹状体）和背侧纹状体同居和交配后（CM），以确定这些神经递质的差异是否可以在MP田鼠对键形成延迟的基础。我们的数据表明，MP田鼠比BP田鼠接受更少的舔/理毛，但没有发现组间的发展差异。没有发现差异的嗅觉线索的检测和区分或偏好性相关的气味，因为所有组天生喜欢异性的气味。在性行为的表现上没有发现差异。然而，CM诱导的加强属性，只有在BP男性，其次是他们的性伴侣的BP，但不MP男性的偏好。BP男性表现出增加多巴胺营业额（DOPAC/DA和HVA/DA）在脑桥核相比，MP田鼠。在背侧纹状体中没有发现多巴胺、5-羟色胺或其代谢产物的差异。我们的研究结果表明，MP田鼠，收到较少舔行为表现出延迟配对债券的形成可能是因为性互动是不够的奖励。
Around 5% of mammals are socially monogamous and both parents provide care to the pups (biparental, BP). Prairie voles are socially monogamous rodents extensively used to understand the neurobiological basis of pair bond formation and the consequences that the absence of one parent has in the offspring. Pair bonding, characterized by selective affiliation with a sexual partner, is facilitated in prairie voles by mating for 6 h or cohabitation without mating for 24 h. It was previously shown that prairie voles raised by their mother alone (monoparental, MP) show delayed pair bond formation upon reaching adulthood. In this study we evaluated the effects of BP and MP care provided on the offspring’s development, ability to detect olfactory cues, preference for sexually relevant odors, display of sexual behavior, as well as the rewarding effects of mating. We also measured dopamine and serotonin concentration in the nucleus accumbens (ventral striatum) and dorsal striatum after cohabitation and mating (CM) to determine if differences in these neurotransmitters could underlie the delay in pair bond formation in MP voles. Our data showed that MP voles received less licking/grooming than BP voles, but no developmental differences between groups were found. No differences were found in the detection and discrimination of olfactory cues or preference for sexually relevant odors, as all groups innately preferred opposite sex odors. No differences were found in the display of sexual behavior. However, CM induced reinforcing properties only in BP males, followed by a preference for their sexual partner in BP but not MP males. BP males showed an increase in dopamine turnover (DOPAC/DA and HVA/DA) in the nucleus accumbens in comparison to MP voles. No differences in dopamine, serotonin or their metabolites were found in the dorsal striatum. Our results indicate that MP voles that received less licking behavior exhibit a delay in pair bond formation possibly because the sexual interaction is not rewarding enough.
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影响因子：
3.5
作者：
CARTER, CS;WITT, DM;VOLKENING, D
通讯作者：
VOLKENING, D
DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
3.6
作者：
CARTER, CS;GETZ, LL;ARNOLD, P
通讯作者：
ARNOLD, P
影响因子：
2.7
作者：
Bosch OJ;Pohl TT;Neumann ID;Young LJ
通讯作者：
Young LJ
影响因子：
4.7
作者：
GLOWINSKI, J;IVERSEN, LL
通讯作者：
IVERSEN, LL