Prevalence of myocardial hypertrophy in a population of asymptomatic Swedish Maine coon cats.
Prevalence of myocardial hypertrophy in a population of asymptomatic Swedish Maine coon cats.
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无症状瑞典缅因州猫猫种群中心肌肥大的患病率。
DOI：
10.1186/1751-0147-50-22
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发表时间：
2008-06-18
影响因子：
2.1
通讯作者：
Häggström J
中科院分区：
文献类型：
--
作者：
Gundler S;Tidholm A;Häggström J
缅因州的浣熊有一个家族性的倾向，发展肥厚型心肌病（HCM）的证据，常染色体显性遗传方式。目前诊断肥厚型心肌病的主要方法是超声心动图。然而，尚未建立明确的参考标准。本研究的目的是确定瑞典缅因州浣熊中与肥厚型心肌病一致的超声心动图变化的患病率，并将超声心动图测量值与先前发表的参考值进行比较。邀请居住在斯德哥尔摩的饲养者所拥有的所有8个月以上的猫参加本研究，这些猫在2001年2月之前列在瑞典缅因州浣熊饲养者的网站上。对所有猫进行体格检查以及M型和2D超声心动图检查。对42只无症状的缅因州浣熊（10只雄性和32只雌性）进行了检查。猫的年龄范围为0.7 - 9.3岁，平均年龄为4.8 ± 2.3岁。4只猫（9.5%）的舒张期室间隔（IVSd）或左心室游离壁（LVPWd）厚度超过6.0 mm。其中3只猫的肥大为节段性。两只猫（4.8%）二尖瓣收缩期前向运动（SAM），无伴随肥大。5只猫（11.9%）的IVSd或LVPWd超过5.0 mm但小于6.0 mm。根据使用的参考值，本研究中HCM的患病率从9.5%到26.2%不等。我们的研究表明，正常猫的左心室壁厚度为5.0 mm或更小，而不是大多数心脏病学家以前使用的6.0 mm。缅因州浣熊的超声心动图参考值和HCM的诊断标准有待进一步研究。
Maine coon cats have a familial disposition for developing hypertrophic cardiomyopathy (HCM) with evidence of an autosomal dominant mode of inheritance. The current mode to diagnose HCM is by use of echocardiography. However, definite reference criteria have not been established. The objective of the study was to determine the prevalence of echocardigraphic changes consistent with hypertrophic cardiomyopathy in Swedish Maine coon cats, and to compare echocardiographic measurements with previously published reference values. All cats over the age of 8 months owned by breeders living in Stockholm, listed on the website of the Maine Coon breeders in Sweden by February 2001, were invited to participate in the study. Physical examination and M-mode and 2D echocardiographic examinations were performed in all cats. Examinations of 42 asymptomatic Maine coon cats (10 males and 32 females) were performed. The age of the cats ranged from 0,7 to 9,3 years with a mean of 4,8 ± 2,3 years. Four cats (9,5%) had a diastolic interventricular septal (IVSd) or left ventricular free wall (LVPWd) thickness exceeding 6,0 mm. In 3 of these cats the hypertrophy was segmental. Two cats (4,8%) had systolic anterior motion (SAM) of the mitral valve without concomitant hypertrophy. Five cats (11,9%) had IVSd or LVPWd exceeding 5,0 mm but less than 6,0 mm. Depending on the reference values used, the prevalence of HCM in this study varied from 9,5% to 26,2%. Our study suggests that the left ventricular wall thickness of a normal cat is 5,0 mm or less, rather than 6,0 mm, previously used by most cardiologists. Appropriate echocardiographic reference values for Maine coon cats, and diagnostic criteria for HCM need to be further investigated.
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影响因子：
2.8
作者：
LIU, SK;ROBERTS, WC;MARON, BJ
通讯作者：
MARON, BJ
DOI：
10.2460/javma.2005.226.734
发表时间：
2005-03-01
影响因子：
1.9
作者：
Drourr, L;Lefbom, BK;Tyrrell, WD
通讯作者：
Tyrrell, WD
DOI：
10.5326/15473317-35-4-285
发表时间：
1999-07-01
影响因子：
1.3
作者：
Bright, JM;Herrtage, ME;Schneider, JF
通讯作者：
Schneider, JF
影响因子：
37.8
作者：
SAHN, DJ;DEMARIA, A;WEYMAN, A
通讯作者：
WEYMAN, A
影响因子：
37.8
作者：
Kittleson, MD;Meurs, KM;Towbin, JA
通讯作者：
Towbin, JA