Mortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score.
Mortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score.
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DOI：
10.1038/s41598-021-93588-9
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发表时间：
2021-07-09
影响因子：
4.6
通讯作者：
Shinozaki G
中科院分区：
文献类型：
--
作者：
Yamanashi T;Marra PS;Crutchley KJ;Wahba NE;Malicoat JR;Sullivan EJ;Akers CC;Nicholson CA;Herrmann FM;Karam MD;Noiseux NO;Kaneko K;Shinozaki E;Iwata M;Cho HR;Lee S;Shinozaki G
我们先前已经开发了一种双频谱脑电图（BSEEG）设备，该设备被证明可以有效地检测谵妄和预测患者的预后。在这项研究中，我们的目的是将BSEEG方法应用于脓毒症。这是一项在单中心进行的回顾性队列研究。根据回顾性病历审查确定脓毒症阳性病例。EEG原始数据和计算的BSEEG评分在先前的研究中获得。分析BSEEG评分与脓毒症的关系，以及脓毒症、BSEEG评分和死亡率之间的关系。分析了628例患者的数据。第一次就诊（第一次BSEEG）的BSEEG评分显示脓毒症患者和非脓毒症患者之间存在显著差异（p = 0.0062），尽管AUC非常小，表明其不适合用于检测目的。BSEEG评分高的脓毒症患者死亡率最高，BSEEG评分低的非脓毒症患者死亡率最低。BSEEG评分高的非脓毒症患者的死亡率与BSEEG评分低的脓毒症患者一样糟糕。即使调整了年龄、性别、合并症和脓毒症状态，BSEEG仍然是死亡率的重要预测因子（p = 0.008）。这些数据证明了其作为识别高风险患者和管理脓毒症的潜在工具的有用性。
We have previously developed a bispectral electroencephalography (BSEEG) device, which was shown to be effective in detecting delirium and predicting patient outcomes. In this study we aimed to apply the BSEEG approach for a sepsis. This was a retrospective cohort study conducted at a single center. Sepsis-positive cases were identified based on retrospective chart review. EEG raw data and calculated BSEEG scores were obtained in the previous studies. The relationship between BSEEG scores and sepsis was analyzed, as well as the relationship among sepsis, BSEEG score, and mortality. Data were analyzed from 628 patients. The BSEEG score from the first encounter (1st BSEEG) showed a significant difference between patients with and without sepsis (p = 0.0062), although AUC was very small indicating that it is not suitable for detection purpose. Sepsis patients with high BSEEG scores showed the highest mortality, and non-sepsis patients with low BSEEG scores showed the lowest mortality. Mortality of non-sepsis patients with high BSEEG scores was as bad as that of sepsis patients with low BSEEG scores. Even adjusting for age, gender, comorbidity, and sepsis status, BSEEG remained a significant predictor of mortality (p = 0.008). These data are demonstrating its usefulness as a potential tool for identification of patients at high risk and management of sepsis.
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DOI：
10.1186/s13054-014-0674-y
发表时间：
2014-12-08
期刊：
Critical care (London, England)
影响因子：
--
作者：
Hosokawa K;Gaspard N;Su F;Oddo M;Vincent JL;Taccone FS
通讯作者：
Taccone FS
DOI：
10.1001/jama.2016.0288
发表时间：
2016-02-23
期刊：
JAMA
影响因子：
--
作者：
Seymour CW;Liu VX;Iwashyna TJ;Brunkhorst FM;Rea TD;Scherag A;Rubenfeld G;Kahn JM;Shankar-Hari M;Singer M;Deutschman CS;Escobar GJ;Angus DC
通讯作者：
Angus DC
影响因子：
3.7
作者：
Azabou E;Magalhaes E;Braconnier A;Yahiaoui L;Moneger G;Heming N;Annane D;Mantz J;Chrétien F;Durand MC;Lofaso F;Porcher R;Sharshar T;Groupe d'Explorations Neurologiques en Réanimation (GENER)
通讯作者：
Groupe d'Explorations Neurologiques en Réanimation (GENER)
影响因子：
2.4
作者：
YOUNG, GB;BOLTON, CF;WELLS, GA
通讯作者：
WELLS, GA
影响因子：
38.9
作者：
Gilmore, Emily J.;Gaspard, Nicolas;Hirsch, Lawrence J.
通讯作者：
Hirsch, Lawrence J.