Screening diagnosis of executive dysfunction after ischemic stroke and the effects of transcranial magnetic stimulation: A prospective functional near-infrared spectroscopy study.
Screening diagnosis of executive dysfunction after ischemic stroke and the effects of transcranial magnetic stimulation: A prospective functional near-infrared spectroscopy study.
复制标题
DOI：
10.1111/cns.14118
复制
发表时间：
2023-06
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
缺血性卒中后执行功能障碍（PISEI）是患者重返社会的严重障碍，目前难以早期筛查且临床无效。本研究旨在阐明功能性近红外光谱（fNIRS）是否可作为PISEI的快速筛查工具，并探讨经颅磁刺激（TMS）对PISEI患者的疗效及脑功能的变化。采用单盲、随机对照研究设计，通过fNIIRS分别检测16例PISEI患者和16例健康受试者在静息状态和Stroop任务期间的血流动力学差异。3天后，所有受试者接受单次TMS干预，并在TMS干预前和干预后3天同时进行Stroop任务的fNIRS测试。与静息状态相比，PISEI患者在Stroop任务期间左背外侧前额叶皮层（DLPFC），右前运动皮层（PMC）和右初级感觉运动皮层（SM 1）中的HbO 2含量显著较高（F = 141.966，p < 0.001），但显著低于健康受试者（T =-3.413，p = 0.002）。经颅磁刺激干预后，PISEI患者的Stroop测试时间和错误次数评分均显著增强，上述脑区的功能活动较基线时显著活跃，而彼此之间的功能联系强度也显著增强。fNIRS有助于筛查和诊断PISEI。单次TMS治疗使PISEI患者受益，效果持续3天，这可能是由于激活了左侧DLPFC，右侧PMC和右侧SM 1脑区。fNIRS可作为PISEI的辅助诊断工具。TMS对PISEI患者有一定的治疗作用，且效果可维持3天，这可能是由于激活了左侧DLPFC、右侧PMC和SM 1脑区，增强了神经重塑的协同作用。
Post‐ischemic stroke executive impairment (PISEI) is a serious obstacle for patients to returning to their society and is currently difficult to screen early and clinically ineffective. The aim of the study was to clarify whether functional near‐infrared spectroscopy (fNIRS) can be used as a rapid screening tool for PISEI and to explore the efficacy of transcranial magnetic stimulation (TMS) in PISEI patients and the changes in brain function. A single‐blind, randomized controlled study design was used to detect hemodynamic differences by fNIIRS in 16 PISEI patients and 16 healthy subjects during the resting state and Stroop task, respectively. After 3 days, all subjects received a single TMS intervention and underwent simultaneous fNIRS testing for the Stroop task before and 3 days after the TMS intervention. PISEI patients had significantly higher HbO2 content in the left dorsolateral prefrontal cortex (DLPFC), the right pre‐motor cortex (PMC) and the right primary sensorimotor cortex (SM1) during the Stroop task compared to the resting state (F = 141.966, p < 0.001), but significantly lower than healthy subjects (T = −3.413, p = 0.002). After TMS intervention, PISEI patients' time and error number scores on the Stroop test were significantly enhanced, and the functional activity of the above‐mentioned brain regions was significantly more active than at baseline, while the strength of their functional connections with each other was markedly increased. fNIRS helped screen and diagnose PISEI. A single TMS session benefited PISEI patients with effects lasting 3 days, which may be attributed to activation of the left DLPFC, right PMC and right SM1 brain regions. fNIRS can be used as an auxiliary diagnostic tool for PISEI. TMS has a certain therapeutic effect on PISEI patients, and the effect can be maintained for 3 days, which may be attributed to the activation of left DLPFC, right PMC and SM1 brain regions and the enhancement of synergism of neural remodeling.
登录
查看更多内容
影响因子：
48
作者：
Gottesman, Rebecca F.;Hillis, Argye E.
通讯作者：
Hillis, Argye E.
DOI：
10.3390/diagnostics11020227
发表时间：
2021-02-03
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Hara T;Shanmugalingam A;McIntyre A;Burhan AM
通讯作者：
Burhan AM
根据持续视觉空间注意力期间的预期 HbO 活动预测 N2pc：一项并行的 fNIRS-ERP 研究
影响因子：
5.7
作者：
Huang, Jing;Wang, Fang;Song, Yan
通讯作者：
Song, Yan
影响因子：
8.3
作者：
McGovern, Aine;Pendlebury, Sarah T.;Quinn, Terence J.
通讯作者：
Quinn, Terence J.
经颅磁刺激对卒中后日常生活活动能力和注意力功能的影响：随机对照试验
影响因子：
3
作者：
Liu, Yuanwen;Yin, Mingyu;Hu, Xiquan
通讯作者：
Hu, Xiquan