Chemically-Gated and Sustained Molecular Transport through Nanoporous Gold Thin Films in Biofouling Conditions.
Chemically-Gated and Sustained Molecular Transport through Nanoporous Gold Thin Films in Biofouling Conditions.
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在生物污染条件下通过纳米多孔金薄膜的化学门控和持续分子传输
DOI：
10.3390/nano11020498
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发表时间：
2021-02-16
期刊：
影响因子：
--
通讯作者：
Seker E
中科院分区：
文献类型：
--
作者：
Palanisamy B;Goshi N;Seker E
药物储库的持续释放和补充对于植入式给药装置的长期功能至关重要。本研究展示了纳米多孔金（np - Au）薄膜用于荧光素（一种小分子药物替代物）从远端储库到释放部位在大（毫米级）距离上的面内传输，从而建立了恒定的分子释放通量。在无卤化物的情况下，由于荧光素与孔壁之间强烈的非特异性相互作用，荧光素的传输可忽略不计。然而，在存在生理相关浓度的离子时，卤化物优先吸附在金表面，使荧光素 - 金相互作用最小化，从而实现面内荧光素传输。此外，纳米多孔膜作为一种内在的尺寸排阻基质，可在生物污染条件（稀释血清）下持续释放。分子释放可通过响应储库（源）和释放部位（汇）处卤化物的存在进行门控来可重复地控制，而无需外部触发（例如，电和机械触发）。
Sustained release and replenishment of the drug depot are essential for the long-term functionality of implantable drug-delivery devices. This study demonstrates the use nanoporous gold (np-Au) thin films for in-plane transport of fluorescein (a small-molecule drug surrogate) over large (mm-scale) distances from a distal reservoir to the site of delivery, thereby establishing a constant flux of molecular release. In the absence of halides, the fluorescein transport is negligible due to a strong non-specific interaction of fluorescein with the pore walls. However, in the presence of physiologically relevant concentration of ions, halides preferentially adsorb onto the gold surface, minimizing the fluorescein–gold interactions and thus enabling in-plane fluorescein transport. In addition, the nanoporous film serves as an intrinsic size-exclusion matrix and allows for sustained release in biofouling conditions (dilute serum). The molecular release is reproducibly controlled by gating it in response to the presence of halides at the reservoir (source) and the release site (sink) without external triggers (e.g., electrical and mechanical).
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影响因子：
3.3
作者：
Casalini, Tommaso;Salvalaglio, Matteo;Cavallotti, Carlo
通讯作者：
Cavallotti, Carlo
影响因子：
13.6
作者：
Acar, Elif Turker;Buchsbaum, Steven F.;Siwy, Zuzanna S.
通讯作者：
Siwy, Zuzanna S.
影响因子：
6.7
作者：
Chapman CA;Wang L;Biener J;Seker E;Biener MM;Matthews MJ
通讯作者：
Matthews MJ
DOI：
10.3390/nano11010208
发表时间：
2021-01-15
期刊：
Nanomaterials (Basel, Switzerland)
影响因子：
--
作者：
Bhattarai JK;Neupane D;Nepal B;Demchenko AV;Stine KJ
通讯作者：
Stine KJ
影响因子：
41.2
作者：
Fujita, Takeshi;Guan, Pengfei;Chen, Mingwei
通讯作者：
Chen, Mingwei