Nanoporous Gold Monolith for High Loading of Unmodified Doxorubicin and Sustained Co-Release of Doxorubicin-Rapamycin.
Nanoporous Gold Monolith for High Loading of Unmodified Doxorubicin and Sustained Co-Release of Doxorubicin-Rapamycin.
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DOI：
10.3390/nano11010208
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发表时间：
2021-01-15
期刊：
影响因子：
--
通讯作者：
Stine KJ
中科院分区：
文献类型：
--
作者：
Bhattarai JK;Neupane D;Nepal B;Demchenko AV;Stine KJ
纳米粒(NPs)被广泛用于传递抗癌药物阿霉素(DOX)，以将心脏毒性降至最低。然而，它们的效率受到化学修饰DOX和/或NPs的必要性以及给药的NPs在肿瘤上的低沉积的影响。因此，应开发替代策略，以提高治疗效果，减少毒性。在这里，我们报告了使用整体式纳米多孔金(NP-Au)棒作为植入物输送DOX的可能性。NP-Au具有很高的包封率(~gt；98%)，最大载药量为93.4mgcm−3，不需要对DOX或NP-Au进行任何化学修饰。我们为DOX在NP-Au中的高负载量提供了一种合理的机制。在37℃、不同pH条件下，药物从NP-Au中缓释26天，并用紫外-可见光谱进行监测。此外，我们还用雷帕霉素(RapA)包埋载药的NP-Au和雷帕霉素(RAPA)-聚(D，L-丙交酯-乙交酯)(PLGA)制备了NP-Au@PLGA/RAPA植入物，并优化了DOX和RAPA的组合释放。进一步利用NP-Au和NP-Au@PLGA/RAPA周围蛋白质的电晕效应，显示了DOX的零级释放动力学。这项工作证明了基于NP-Au的植入物具有作为DOX载体在癌症治疗中的潜在应用的潜力。
Nanoparticles (NPs) have been widely explored for delivering doxorubicin (DOX), an anticancer drug, to minimize cardiotoxicity. However, their efficiency is marred by a necessity to chemically modify DOX, NPs, or both and low deposition of the administered NPs on tumors. Therefore, alternative strategies should be developed to improve therapeutic efficacy and decrease toxicity. Here we report the possibility of employing a monolithic nanoporous gold (np-Au) rod as an implant for delivering DOX. The np-Au has very high DOX encapsulation efficiency (>98%) with maximum loading of 93.4 mg cm−3 without any chemical modification required of DOX or np-Au. We provide a plausible mechanism for the high loading of DOX in np-Au. The DOX sustained release for 26 days from np-Au in different pH conditions at 37 °C, which was monitored using UV-Vis spectroscopy. Additionally, we encased the DOX-loaded np-Au with rapamycin (RAPA)-trapped poly(D,L-lactide-co-glycolide) (PLGA) to fabricate an np-Au@PLGA/RAPA implant and optimized the combinatorial release of DOX and RAPA. Further exploiting the effect of the protein corona around np-Au and np-Au@PLGA/RAPA showed zero-order release kinetics of DOX. This work proves that the np-Au-based implant has the potential to be used as a DOX carrier of potential use in cancer treatment.
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影响因子：
62.1
作者：
Kamaly N;Yameen B;Wu J;Farokhzad OC
通讯作者：
Farokhzad OC
刺激响应聚合物电极接口的合理设计与体内微透析相结合，用于测量阿尔茨海默氏病活体小鼠大脑中的唾液酸
影响因子：
8.9
作者：
Ding, Shushu;Cao, Sumei;Shi, Guoyue
通讯作者：
Shi, Guoyue
多孔PLGA微球协同递送阿霉素和紫杉醇用于肺部吸入治疗
DOI：
10.1016/j.ejpb.2014.09.012
发表时间：
2014-11-01
影响因子：
4.9
作者：
Feng, Tianshi;Tian, Huayu;Chen, Xuesi
通讯作者：
Chen, Xuesi
影响因子：
17.1
作者：
Kang M;Jung S;Zhang H;Kang T;Kang H;Yoo Y;Hong JP;Ahn JP;Kwak J;Jeon D;Kotov NA;Kim B
通讯作者：
Kim B
影响因子：
9.5
作者：
Chapman CA;Chen H;Stamou M;Biener J;Biener MM;Lein PJ;Seker E
通讯作者：
Seker E