Cortical Bone Mass is Low in Boys with Klinefelter Syndrome and Improves with Oxandrolone.
Cortical Bone Mass is Low in Boys with Klinefelter Syndrome and Improves with Oxandrolone.
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DOI：
10.1210/jendso/bvab016
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发表时间：
2021-04-01
影响因子：
4.1
通讯作者：
Ross JL
中科院分区：
文献类型：
--
作者：
Vogiatzi MG;Davis SM;Ross JL
Klinefelter综合征（KS）是男性最常见的性非整倍体。受影响的男性性腺功能减退，因此，面临骨质疏松症和骨折的风险增加。雄激素治疗是青少年和成人KS患者的标准治疗方法，但在儿童早期并未使用。目的：探讨雄激素治疗对儿童骨量的影响。随机、双盲、安慰剂对照临床试验奥雄龙（OX； 0.06 mg/kg每日；n = 38）与安慰剂（PL; n = 40）在患有KS的男孩（4-12岁）中持续2年。通过数字x线放射测量测量骨量的变化，确定骨健康指数（BHI）和标准差评分（SDS）。基线时各组间BHI SDS相似（-0.46±1.1 vs -0.34±1.0 OX vs PL, P >）。OX组与PL组在2年时（-0.1±1.3 vs -0.53±0.9,P < 0.01）高于OX组（P < 0.01）。基线时，所有受试者的BHI SDS值均非正态分布，25.7%的受试者绘制在-1 SDS以下(P <。001)，表明骨量不足。总共有13.5%的受试者发生骨折，其BHI SDS低于无骨折者（-1.6±1.3 vs -0.3±1.0,P = 0.004）。一些患有KS的儿童使用BHI SDS骨量减少，而患有OX的儿童骨量增加。由于这些个体有骨质疏松症的风险，适合年龄的雄激素替代和未来对KS儿童骨骼健康的研究应进一步探索。
Klinefelter syndrome (KS) is the most common sex aneuploidy in men. Affected males have hypogonadism, and, as a result, face an increased risk for osteoporosis and fractures. Androgen therapy is standard in adolescents and adults with KS but has not been used earlier in childhood. To determine the effects of androgen treatment on bone mass in children with KS. Randomized, double-blind, placebo-controlled clinical trial of oxandrolone (OX; 0.06 mg/kg daily; n = 38) versus placebo (PL; n = 40) for 2 years in boys with KS (ages 4-12 years). Changes in bone mass were examined by digital x-ray radiogrammetry, which determines the Bone Health Index (BHI) and standard deviation score (SDS). BHI SDS was similar between groups at baseline (–0.46 ± 1.1 vs –0.34 ± 1.0 OX vs PL, P > .05) and higher in the OX group at 2 years (–0.1 ± 1.3 vs –0.53 ± 0.9, OX vs PL, P < .01). At baseline, BHI SDS values of all subjects were not normally distributed with 25.7% of subjects plotted below –1 SDS (P < .001), suggesting a deficit in bone mass. In total, 13.5% of subjects had sustained a fracture and their BHI SDS was lower than those with no fractures (–1.6 ± 1.3 vs –0.3 ± 1.0, P = .004). Bone mass using BHI SDS is reduced in some children with KS and improves with OX. Since these individuals are at risk for osteoporosis, age-appropriate androgen replacement and future studies on bone health in children with KS should be further explored.
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影响因子：
4.3
作者：
Clark, Emma M.
通讯作者：
Clark, Emma M.
影响因子：
5.2
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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