The Bruce effect: Representational stability and memory formation in the accessory olfactory bulb of the female mouse.
The Bruce effect: Representational stability and memory formation in the accessory olfactory bulb of the female mouse.
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DOI：
10.1016/j.celrep.2022.111262
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发表时间：
2022-08-23
期刊：
影响因子：
8.8
通讯作者：
Ben-Shaul, Yoram
中科院分区：
文献类型：
--
作者：
Yoles-Frenkel, Michal;Shea, Stephen D.;Davison, Ian G.;Ben-Shaul, Yoram
在布鲁斯效应中，一只交配的雌性小鼠对雄鼠的妊娠阻断效应产生了抵抗力。各种证据表明，这种形式的行为印记是由于雌性小鼠的辅助嗅球（AOB）对雄鼠化学信号的敏感性降低所致。然而，AOB的组合代码意味着对一个人的反应减弱会扭曲其他刺激的表现。在这里，我们记录细胞外的AOB神经元的反应，在交配和未交配的雌性小鼠，同时提出尿液刺激的螺柱和其他来源。我们发现，虽然AOB中的初始感觉反应（在指导社会互动所需的时间尺度内）保持稳定，但对延长刺激（如引发妊娠阻滞所需）的反应显示出对螺柱反应神经元的选择性衰减。这种暂时的分离可以允许以刺激特异性的方式衰减缓慢作用的内分泌过程，而不会损害指导行为的持续表征。在研究布鲁斯效应的神经元相关性时，Yoles-Frenkel等人记录了雌性小鼠副嗅球（AOB）中对化学感觉线索的神经元反应。他们发现，虽然多种刺激的即时神经元表征在交配后保持稳定，但对螺柱刺激的延长呈现导致反应减弱。
In the Bruce effect, a mated female mouse becomes resistant to the pregnancy-blocking effect of the stud. Various lines of evidence suggest that this form of behavioral imprinting results from reduced sensitivity of the female’s accessory olfactory bulb (AOB) to the stud’s chemosignals. However, the AOB’s combinatorial code implies that diminishing responses to one individual will distort representations of other stimuli. Here, we record extracellular responses of AOB neurons in mated and unmated female mice while presenting urine stimuli from the stud and from other sources. We find that, while initial sensory responses in the AOB (within a timescale required to guide social interactions) remain stable, responses to extended stimulation (as required for eliciting the pregnancy block) display selective attenuation of stud-responsive neurons. Such temporal disassociation could allow attenuation of slow-acting endocrine processes in a stimulus-specific manner without compromising ongoing representations that guide behavior. Studying the neuronal correlates of the Bruce effect, Yoles-Frenkel et al. record neuronal responses to chemosensory cues in the accessory olfactory bulb (AOB) of female mice. They find that, while immediate neuronal representations of multiple stimuli remain stable following mating, extended presentation of the stud stimulus leads to attenuated responses.
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