Infant urinary metabolomic profile in a fatal acute methadone intoxication.
Infant urinary metabolomic profile in a fatal acute methadone intoxication.
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DOI：
10.1007/s00414-021-02772-z
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发表时间：
2022-03
影响因子：
2.1
通讯作者：
Locci E
中科院分区：
文献类型：
--
作者：
Chighine A;Porcu M;Ferino G;Lenigno N;Trignano C;d'Aloja E;Locci E
本文报告一例疑似婴儿猝死综合征的病例。病理结果与急性呼吸衰竭一致，而毒理学分析显示血液美沙酮浓度升高。死亡被归因于急性美沙酮中毒。除了尸检方法外，还采用1H NMR代谢组学方法研究了尸检时采集的尿液样本，并采用先前从10例围产期窒息新生儿和16例健康对照新生儿中获得的尿液代谢组学特征对确定的代谢组学特征进行了挑战。有趣的是，美沙酮中毒婴儿的尿液特征与围产期窒息新生儿的尿液特征非常相似，特别是与结局最差的新生儿的尿液特征非常相似。结果提供了几个提示之间的窒息/缺氧的不同机制的共享代谢紊乱。据作者所知，这是第一份在病理病例中使用代谢组学方法的报告，其中代谢组学提供了关于死亡机制和原因的有用的额外信息。
A case report suspicious for a Sudden Infant Death Syndrome is here described. Pathological findings were consistent with an acute respiratory failure while toxicological analysis revealed an elevated blood methadone concentration. Death was then ascribed to an acute methadone intoxication. In addition to the routinary approach, the urinary sample collected at autopsy was investigated with a 1H NMR metabolomic approach and the identified metabolomic profile was challenged with the urinary metabolomic profiles previously obtained from 10 newborns who experienced perinatal asphyxia and 16 healthy control newborns. Intriguingly, the urinary profile of the methadone intoxicated infant was very similar to those belonging to the perinatal asphyxia newborns, especially to those belonging to the newborns characterised by the worst outcome. The results offer several hints on a shared metabolic derangement between different mechanisms of asphyxia/hypoxia. To the best of the authors’ knowledge, this is the first report of the use of a metabolomic approach in a pathological case, in which metabolomics offers useful additional information regarding the mechanism and the cause of death.
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影响因子：
3.4
作者：
Lyu L;Sonik N;Bhattacharya S
通讯作者：
Bhattacharya S
影响因子：
2.1
作者：
Bajanowski, T.;Brinkmann, B.;Vennemann, M.
通讯作者：
Vennemann, M.
影响因子：
3.9
作者：
Wang, JS;DeVane, CL
通讯作者：
DeVane, CL
影响因子：
6.7
作者：
Eap, C. B.;Crettol, S.;Abriel, H.
通讯作者：
Abriel, H.
DOI：
10.1007/s11306-020-01743-6
发表时间：
2020-11-07
期刊：
Metabolomics : Official journal of the Metabolomic Society
影响因子：
--
作者：
Locci E;Bazzano G;Chighine A;Locco F;Ferraro E;Demontis R;d'Aloja E
通讯作者：
d'Aloja E