Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls.
Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls.
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DOI：
10.1016/j.neuroimage.2010.10.060
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发表时间：
2011-02-14
期刊：
影响因子：
5.7
通讯作者：
Fowler JS
中科院分区：
文献类型：
--
作者：
Tomasi D;Volkow ND;Wang GJ;Wang R;Telang F;Caparelli EC;Wong C;Jayne M;Fowler JS
哌醋甲酯（MPH）是一种刺激性药物，可以放大大脑中的多巴胺和去甲肾上腺素能信号，这被认为是其认知增强作用的基础。然而，MPH改善认知的神经生物学作用仍然知之甚少。在这里，功能性磁共振成像（fMRI）与工作记忆（WM）和视觉注意（VA）任务一起使用，以检验20 mg口服MPH将增加背侧注意网络（DAN）的激活和默认模式网络（DMN）的失活以及提高健康男性在认知任务中的表现的假设。接受MPH的受试者组（MPH组; N = 16）比未接受药物治疗的受试者组具有更高的激活（对照组：N = 16）在DAN地区（顶叶和前额叶皮层，随着认知负荷的增加，大脑皮层和后扣带皮层的激活增加（随着认知负荷的增加，区域越来越失活），这些影响在VA和WM任务中没有差异。这些发现提供了第一个证据，MPH增强激活的DAN，而它改变DMN失活。这表明MPH（可能是通过放大多巴胺和去甲肾上腺素能信号）部分地通过其对DAN和DMN的影响来调节认知。
Methylphenidate (MPH) is a stimulant drug that amplifies dopamineric and noradrenergic signaling in the brain, which is believed to underlie its cognition enhancing effects. However, the neurobiological effects by which MPH improves cognition are still poorly understood. Here, functional magnetic resonance imaging (fMRI) was used together with working memory (WM) and visual attention (VA) tasks to test the hypothesis that 20 mg oral MPH would increase activation in the dorsal attention network (DAN) and deactivation in the default mode network (DMN) as well as improve performance during cognitive tasks in healthy men. The group of subjects that received MPH (MPH group; N = 16) had higher activation than the group of subjects who received no medication (control group: N = 16) in DAN regions (parietal and prefrontal cortex, regions increasingly activated with increased cognitive load) and had increased deactivation in the insula and posterior cingulate cortex (regions increasingly deactivated with increased cognitive load) and these effects did not differ for the VA and the WM tasks. These findings provide the first evidence that MPH enhances activation of the DAN whereas it alters DMN deactivation. This suggests that MPH (presumably by amplifying dopamine and noradrenergic signaling) modulates cognition in part through its effects on DAN and DMN.
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影响因子：
5.1
作者：
Caparelli, E. C.;Tomasi, D.
通讯作者：
Tomasi, D.
影响因子：
5.7
作者：
Caparelli, EC;Tomasi, D;Ernst, T
通讯作者：
Ernst, T
影响因子：
3.4
作者：
Elliott, R;Sahakian, BJ;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
56.9
作者：
de Fockert, JW;Rees, G;Lavie, N
通讯作者：
Lavie, N
DOI：
10.1073/pnas.0810650105
发表时间：
2008-12-09
影响因子：
11.1
作者：
Izquierdo, Ivan;Bevilaqua, Lia R.;Cammarota, Martin
通讯作者：
Cammarota, Martin