Periodontal disease is an independent predictor of intracardiac calcification.
Periodontal disease is an independent predictor of intracardiac calcification.
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DOI：
10.1155/2013/854340
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发表时间：
2013
影响因子：
--
通讯作者：
Figueredo VM
中科院分区：
文献类型：
--
作者：
Pressman GS;Qasim A;Verma N;Miyamae M;Arishiro K;Notohara Y;Crudu V;Figueredo VM
背景。牙周炎是世界范围内最常见的慢性炎症，与冠心病的发生有关。假设。我们假设牙周病也可能与心脏钙化有关，心脏钙化与动脉粥样硬化有许多共同的危险因素，被认为是亚临床动脉粥样硬化的标志。方法。横断面研究在两个地点（美国和日本）涉及受试者的临床超声心动图和详细的牙科检查。采用半定量评分系统评估牙周病和超声心动图钙化的严重程度。结果。73名受试者中有56名（77%）患有心脏钙化，51%患有中度至重度牙周病（评分为bbbb2）。在未经调整的分析中，发现牙周评分与心脏钙化之间存在显著关系（Spearman rho = 0.4, P = 0.001），随着牙周疾病水平的增加，平均钙化评分也会增加。对年龄、性别、种族、肾小球滤过率和传统危险因素进行校正后的多因素logistic回归显示，这种相关性仍然显著（P = 0.024）。研究地点、种族或性别之间没有显著的相互作用。结论。在多种族人群中，我们发现牙周病（慢性炎症）程度与心脏钙化之间存在显著关联。此外，牙周评分越高，钙化程度越高。
Background. Periodontitis is the most common chronic inflammatory condition worldwide and is associated with incident coronary disease. Hypothesis. We hypothesized that periodontal disease would also be associated with cardiac calcification, a condition which shares many risk factors with atherosclerosis and is considered a marker of subclinical atherosclerosis. Methods. Cross-sectional study at two sites (USA and Japan) involving subjects with both clinical echocardiograms and detailed dental examinations. Semiquantitative scoring systems were used to assess severity of periodontal disease and echocardiographic calcification. Results. Fifty-six of 73 subjects (77%) had cardiac calcifications, and 51% had moderate to severe periodontal disease (score > 2). In unadjusted analysis, a significant relationship between periodontal score and cardiac calcification (Spearman rho = 0.4, P = 0.001) was noted, with increases in mean calcification score seen across increasing levels of periodontal disease. On multivariate logistic regression, adjusted for age, gender, race, glomerular filtration rate, and traditional risk factors, this association remained significant (P = 0.024). There was no significant interaction by study site, race, or gender. Conclusions. In a multiracial population, we found a significant association between the degree of periodontal disease, a chronic inflammatory condition, and cardiac calcification. Further, higher periodontal scores were associated with greater degrees of calcification.
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DOI：
10.1016/s0735-1097(00)01130-x
发表时间：
2001-02-01
影响因子：
24
作者：
Howell, TH;Ridker, PM;Christen, WG
通讯作者：
Christen, WG
DOI：
10.1016/s0735-1097(01)01678-3
发表时间：
2001-12-01
影响因子：
24
作者：
Jeon, DS;Atar, S;Siegel, RJ
通讯作者：
Siegel, RJ
影响因子：
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作者：
Jesri, Ammar;Braitman, Leonard E.;Pressman, Gregg S.
通讯作者：
Pressman, Gregg S.
影响因子：
5.3
作者：
Sharma, Rajan;Pellerin, Denis;Brecker, Stephen J. D.
通讯作者：
Brecker, Stephen J. D.
影响因子：
158.5
作者：
Tonetti, Maurizio S.;D'Aiuto, Francesco;Deanfield, John
通讯作者：
Deanfield, John