Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys.
Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys.
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DOI：
10.1016/j.neurobiolaging.2010.09.014
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发表时间：
2012-02
影响因子：
4.2
通讯作者：
Rapp PR
中科院分区：
文献类型：
--
作者：
Hara Y;Park CS;Janssen WG;Roberts MT;Morrison JH;Rapp PR
老年恒河猴表现出与老年人相似的大脑皮层依赖性记忆缺陷。在这里，我们探索了认知能力下降的基础，首先测试年轻的成年和老年猴子的标准识别记忆测试（延迟非匹配样本测试; DNMS）。接下来，我们定量海马齿状回（DG）外（OML）和内分子层（IML）中的突触密度和形态。与之前的研究结果一致，老年猴子最初学习DNMS的速度很慢，并且在较长的保留时间间隔下，它们的表现明显不如年轻受试者。虽然OML和IML突触参数未能在年轻组和老年组之间有所不同，但OML中穿孔突触的密度与识别记忆准确性相关联。与实际年龄无关，根据月经数据分类为绝经后/绝经后的猴子在DNMS上的评分更差，并且显示出比绝经前猴子更低的OML穿孔突触密度。这些结果表明，自然发生的生殖衰老可能会影响DG OML的突触连接，从而导致正常认知衰老过程中的个体差异。
Aged rhesus monkeys exhibit deficits in hippocampus-dependent memory, similar to aging humans. Here we explored the basis of cognitive decline by first testing young adult and aged monkeys on a standard recognition memory test (delayed nonmatching-to-sample test; DNMS). Next we quantified synaptic density and morphology in the hippocampal dentate gyrus (DG) outer (OML) and inner molecular layer (IML). Consistent with previous findings, aged monkeys were slow to learn DNMS initially, and they performed significantly worse than young subjects when challenged with longer retention intervals. Although OML and IML synaptic parameters failed to differ across the young and aged groups, the density of perforated synapses in the OML was coupled with recognition memory accuracy. Independent of chronological age, monkeys classified on the basis of menses data as peri/post-menopausal scored worse on DNMS, and displayed lower OML perforated synapse density, than pre-menopausal monkeys. These results suggest that naturally occurring reproductive senescence potently influences synaptic connectivity in the DG OML, contributing to individual differences in the course of normal cognitive aging.
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影响因子：
16.2
作者：
Holtmaat, AJGD;Trachtenberg, JT;Svoboda, K
通讯作者：
Svoboda, K
DOI：
10.1073/pnas.83.9.3027
发表时间：
1986-05-01
影响因子：
11.1
作者：
GEINISMAN, Y;DETOLEDOMORRELL, L;MORRELL, F
通讯作者：
MORRELL, F
影响因子：
2.5
作者：
Calhoun, ME;Mao, Y;Rapp, PR
通讯作者：
Rapp, PR
影响因子：
2.7
作者：
Herndon, JG;Moss, MB;Killiany, RJ
通讯作者：
Killiany, RJ
DOI：
10.1073/pnas.0704757104
发表时间：
2007-07-03
影响因子：
11.1
作者：
Hao, Jiandong;Rapp, Peter R.;Morrison, John H.
通讯作者：
Morrison, John H.