National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK.
National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK.
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DOI：
10.1136/archdischild-2023-325504
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发表时间：
2023-11
影响因子：
4.4
通讯作者：
Gale, Chris
中科院分区：
文献类型：
--
作者：
Evans, Katie;Battersby, Cheryl;Boardman, James P.;Boyle, Elaine;Carroll, Will;Dinwiddy, Kate;Dorling, Jon;Gallagher, Katie;Hardy, Pollyanna;Johnston, Emma;Mactier, Helen;Marcroft, Claire;Webbe, James William Harrison;Gale, Chris
新生儿护理的提供是可变的，通常缺乏足够的证据基础;需要对方法学上稳健的临床试验进行战略性开发，以改善结果并最大限度地利用研究资源。从历史上看，新生儿研究主题已被选定的研究人员;涉及更广泛的利益相关者群体的优先顺序过程中，一般确定的研究主题，而不是具体的问题，适合干预性试验。让包括父母、医疗保健专业人员和研究人员在内的利益相关者参与进来，确定并优先考虑适合在英国新生儿干预性试验中回答的研究问题。研究问题由利益攸关方通过在线平台以人口、干预、比较、结果格式提交。问题由代表性指导小组审查;重复的问题和之前回答的问题已被删除。合格的问题被输入到一个三轮的在线德尔菲调查的优先顺序由所有利益相关者群体。108名受访者提交了研究问题供考虑; 144名参与者完成了德尔菲调查的第一轮，106名完成了所有三轮。共提交了265个研究问题，经过指导小组审查，其中186个进入了德尔菲调查。排在前五位的研究问题涉及母乳强化、完整脊髓复苏、坏死性小肠结肠炎手术干预的时机、轻度缺氧缺血性脑病的治疗性低温和非侵入性呼吸支持。我们已经确定并优先考虑适合于目前英国新生儿医学实践改变干预试验的研究问题。针对这些不确定性的试验有可能减少研究浪费并改善新生儿护理。
The provision of neonatal care is variable and commonly lacks adequate evidence base; strategic development of methodologically robust clinical trials is needed to improve outcomes and maximise research resources. Historically, neonatal research topics have been selected by researchers; prioritisation processes involving wider stakeholder groups have generally identified research themes rather than specific questions amenable to interventional trials. To involve stakeholders including parents, healthcare professionals and researchers to identify and prioritise research questions suitable for answering in neonatal interventional trials in the UK. Research questions were submitted by stakeholders in population, intervention, comparison, outcome format through an online platform. Questions were reviewed by a representative steering group; duplicates and previously answered questions were removed. Eligible questions were entered into a three-round online Delphi survey for prioritisation by all stakeholder groups. One hundred and eight respondents submitted research questions for consideration; 144 participants completed round one of the Delphi survey, 106 completed all three rounds. Two hundred and sixty-five research questions were submitted and after steering group review, 186 entered into the Delphi survey. The top five ranked research questions related to breast milk fortification, intact cord resuscitation, timing of surgical intervention in necrotising enterocolitis, therapeutic hypothermia for mild hypoxic ischaemic encephalopathy and non-invasive respiratory support. We have identified and prioritised research questions suitable for practice-changing interventional trials in neonatal medicine in the UK at the present time. Trials targeting these uncertainties have potential to reduce research waste and improve neonatal care.
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影响因子：
2.9
作者：
Ho, Alison;Webster, Louise;Chappell, Lucy
通讯作者：
Chappell, Lucy
影响因子：
2.9
作者：
Pierrat, Veronique;Burguet, Antoine;Kaminski, Monique
通讯作者：
Kaminski, Monique
影响因子：
--
作者：
Grill C
通讯作者：
Grill C
影响因子：
3.1
作者：
Oliver, Sandy;Uhm, Seilin;Deshpande, Sanjeev
通讯作者：
Deshpande, Sanjeev
DOI：
10.1111/dme.14588
发表时间：
2021-08
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Ayman G;Strachan JA;McLennan N;Malouf R;Lowe-Zinola J;Magdi F;Roberts N;Alderdice F;Berneantu I;Breslin N;Byrne C;Carnell S;Churchill D;Grisoni J;Hirst JE;Morris A;Murphy HR;O'Brien J;Schmutz C;Shah K;Singal AS;Strachan MWJ;Cowan K;Knight M
通讯作者：
Knight M