Organization of long-range inputs and outputs of frontal cortex for top-down control.
Organization of long-range inputs and outputs of frontal cortex for top-down control.
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DOI：
10.1038/nn.4417
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发表时间：
2016-12
影响因子：
25
通讯作者：
Dan, Yang
中科院分区：
文献类型：
--
作者：
Zhang, Siyu;Xu, Min;Chang, Wei-Cheng;Ma, Chenyan;Johnny Phong Hoang Do;Jeong, Daniel;Lei, Tiffany;Fan, Jiang Lan;Dan, Yang
众所周知，额叶皮层的远距离投射可以以多种方式调节感觉处理。尽管小鼠已成为研究行为回路基础的越来越重要的动物模型，但其额叶皮层远程连接的功能组织仍然知之甚少。在这里，我们使用病毒辅助电路映射来识别自上而下调节视觉、体感和听觉处理的大脑网络。视觉皮层与前扣带区相互连接，而体感和听觉皮层则与初级和次级运动皮层相连。顺行和逆行追踪确定了属于每个网络的皮质和皮质下结构。此外，使用新颖的病毒技术来针对投射到视觉皮层和上丘的额叶神经元亚群，我们在视觉网络中确定了两个不同的子网络。这些发现为理解自上而下的行为控制背后的大脑机制提供了解剖学基础。
Long-range projections from the frontal cortex are known to modulate sensory processing in multiple modalities. Although the mouse has become an increasingly important animal model for studying the circuit basis of behavior, the functional organization of its frontal cortical long-range connectivity remains poorly characterized. Here we used virus-assisted circuit mapping to identify the brain networks for top-down modulation of visual, somatosensory, and auditory processing. The visual cortex is reciprocally connected to the anterior cingulate area, whereas the somatosensory and auditory cortices are connected to the primary and secondary motor cortices. Anterograde and retrograde tracing identified the cortical and subcortical structures belonging to each network. Furthermore, using novel viral techniques to target subpopulations of frontal neurons projecting to the visual cortex versus the superior colliculus, we identified two distinct subnetworks within the visual network. These findings provide an anatomical foundation for understanding the brain mechanisms underlying top-down control of behavior.
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影响因子：
15.9
作者：
Lodato S;Shetty AS;Arlotta P
通讯作者：
Arlotta P
影响因子：
13.9
作者：
Fishell G;Rudy B
通讯作者：
Rudy B
影响因子：
5.3
作者：
Morishima, M;Kawaguchi, Y
通讯作者：
Kawaguchi, Y
影响因子：
25
作者：
Lee, Soohyun;Kruglikov, Illya;Huang, Z. Josh;Fishell, Gord;Rudy, Bernardo
通讯作者：
Rudy, Bernardo
影响因子：
16.2
作者：
Euston DR;Gruber AJ;McNaughton BL
通讯作者：
McNaughton BL