Target sites for chemical regulation of strigolactone signaling.
Target sites for chemical regulation of strigolactone signaling.
复制标题
DOI：
10.3389/fpls.2014.00623
复制
发表时间：
2014
影响因子：
5.6
通讯作者：
Asami T
中科院分区：
文献类型：
--
作者：
Nakamura H;Asami T
全球对植物生长调节剂(PGRs；控制植物生长的化学物质)的需求正在增加，特别是在发展中国家。正的和负的PGR分别被广泛地用于提高作物产量和抑制不需要的新梢生长。Strigolactones(SLS)是一类多功能分子，具有植物激素的功能，可以抑制枝条的分枝，也可以与共生真菌和寄生杂草进行根际通讯。因此，预计调节SLS功能的化学物质将在农业应用中得到广泛应用。虽然SL的生物合成途径还不完全清楚，但已经证明β-胡萝卜素异构酶、类胡萝卜素裂解双加氧酶(CCDS)和细胞色素P450单加氧酶参与了木犀草内酯的生物合成。脱落酸生物合成的抑制剂阿巴胺降低了几种植物的SL水平，降低了与烟草共生的Orobanche小种种子的发芽率。根据阿巴胺的结构，已经设计了几种化学物质来特异性地抑制SL合成过程中的CCDs。细胞色素P450单加氧酶是开发SL生物合成抑制剂的另一个靶酶，三氮唑衍生的TIS系列化合物已知包括SL生物合成抑制剂，尽管它们的靶酶尚未确定。最近，DWARF14(D14)被证明是SLS的受体，而SL的D-环部分是其识别D14所必需的。目前正在开发各种SL激动剂，大多数激动剂通常含有D-环或D-环样部分。在过去的两年里，几个研究小组也解决了D14的晶体结构问题。预计这些关于D14结构的信息不仅对于开发具有新结构的SL激动剂，而且对于设计SL受体的抑制剂都是非常有价值的。
Demands for plant growth regulators (PGRs; chemicals that control plant growth) are increasing globally, especially in developing countries. Both positive and negative PGRs are widely used to enhance crop production and to suppress unwanted shoot growth, respectively. Strigolactones (SLs) are multifunctional molecules that function as phytohormones, inhibiting shoot branching and also functioning in the rhizospheric communication with symbiotic fungi and parasitic weeds. Therefore, it is anticipated that chemicals that regulate the functions of SLs will be widely used in agricultural applications. Although the SL biosynthetic pathway is not fully understood, it has been demonstrated that β-carotene isomerases, carotenoid cleavage dioxygenases (CCDs), and a cytochrome P450 monooxygenase are involved in strigolactone biosynthesis. A CCD inhibitor, abamine, which is also an inhibitor of abscisic acid biosynthesis, reduces the levels of SL in several plant species and reduces the germination rate of Orobanche minor seeds grown with tobacco. On the basis of the structure of abamine, several chemicals have been designed to specifically inhibit CCDs during SL synthesis. Cytochrome P450 monooxygenase is another target enzyme in the development of SL biosynthesis inhibitors, and the triazole-derived TIS series of chemicals is known to include SL biosynthesis inhibitors, although their target enzyme has not been identified. Recently, DWARF14 (D14) has been shown to be a receptor for SLs, and the D-ring moiety of SL is essential for its recognition by D14. A variety of SL agonists are currently under development and most agonists commonly contain the D-ring or a D-ring-like moiety. Several research groups have also resolved the crystal structure of D14 in the last two years. It is expected that this information on the D14 structure will be invaluable not only for developing SL agonists with novel structures but also in the design of inhibitors of SL receptors.
登录
查看更多内容
影响因子：
2.7
作者：
Han, SY;Kitahata, N;Asami, T
通讯作者：
Asami, T
影响因子：
9.2
作者：
Hamiaux, Cyril;Drummond, Revel S. M.;Snowden, Kimberley C.
通讯作者：
Snowden, Kimberley C.
DOI：
10.1080/1475636031000080207
发表时间：
2003-05-26
影响因子：
5.6
作者：
Han, SY;Inoue, H;Asami, T
通讯作者：
Asami, T
影响因子：
4.9
作者：
Ito S;Kitahata N;Umehara M;Hanada A;Kato A;Ueno K;Mashiguchi K;Kyozuka J;Yoneyama K;Yamaguchi S;Asami T
通讯作者：
Asami T
影响因子：
2.4
作者：
Ito, Shinsaku;Umehara, Mikihisa;Asami, Tadao
通讯作者：
Asami, Tadao