Gold nanoparticles in breast cancer treatment: promise and potential pitfalls.
Gold nanoparticles in breast cancer treatment: promise and potential pitfalls.
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DOI:
10.1016/j.canlet.2014.02.006
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发表时间:
2014-05-28
期刊:
影响因子:
9.7
通讯作者:
Krishnan, Sunil
中科院分区:
文献类型:
--
作者:
Lee, Jihyoun;Chatterjee, Dev Kumar;Lee, Min Hyuk;Krishnan, Sunil
Despite remarkable achievements in the treatment of breast cancer, some obstacles still remain. Gold nanoparticles may prove valuable in addressing these problems owing to their unique characteristics, including their enhanced permeability and retention in tumor tissue, their light absorbance and surface plasmon resonance in near-infrared light, their interaction with radiation to generate secondary electrons, and their ability to be conjugated with drugs or other agents. Herein, we discuss some basic concepts of gold nanoparticles, and early results from studies regarding their use in breast cancer, including toxicity and side effects. We also discuss these particles’ potential clinical applications.
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