Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells.
Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells.
复制标题
DOI：
10.1021/nl802915q
复制
发表时间：
2009-01
期刊：
影响因子：
10.8
通讯作者：
Motamedi M
中科院分区：
文献类型：
--
作者：
Eghtedari M;Liopo AV;Copland JA;Oraevsky AA;Motamedi M
描述了一种新的技术，使金纳米棒（GNRs）功能化，允许在无胸腺裸鼠中生长的乳腺癌肿瘤的体内靶向。GNR通过赫赛汀（HER）和聚乙二醇（PEG）的共价连接进行功能化，赫赛汀是一种单克隆抗体，能够对表达高度特异性肿瘤相关抗原的乳腺癌细胞进行分子识别，聚乙二醇（PEG）使体内网状内皮系统的颗粒变得模糊。制造的颗粒（Her-PEG GNR）的稳定性和功能性在血液存在下在体外证明，然后在乳腺癌裸鼠模型中在体内证明。结果表明，功能化金纳米棒在荷瘤裸鼠中HER 2/neu过表达乳腺肿瘤内的成功肿瘤积累，并支持GNRs可用于肿瘤分子成像的概念。
A novel technique is described to functionalize gold nanorods (GNRs) allowing for in-vivo targeting of breast cancer tumors grown in athymic nude mice. GNRs were functionalized by covalent attachment of Herceptin (HER), a monoclonal antibody that enables molecular recognition of breast cancer cells expressing highly specific tumor associated antigens, and poly(ethylene glycol) (PEG) which obscures particles against the reticuloendothelial system in the body. The stability and functionality of fabricated particles (Her-PEG GNRs) were demonstrated in-vitro in the presence of blood and then in-vivo in nude mice model for breast cancer. The results demonstrate successful tumor accumulation of functionalized gold nanorods within HER2/neu over-expressing breast tumors in tumor-bearing nude mice and support the notions that GNRs can be used for molecular imaging of tumor.
登录
查看更多内容
影响因子：
3.8
作者：
Adler, Desmond C.;Huang, Shu-Wei;Fujimoto, James G.
通讯作者：
Fujimoto, James G.
影响因子：
15
作者：
Caswell, KK;Wilson, JN;Murphy, CJ
通讯作者：
Murphy, CJ
影响因子：
10.8
作者：
El-Sayed, IH;Huang, XH;El-Sayed, MA
通讯作者：
El-Sayed, MA
影响因子：
2.6
作者：
DITRICH, H;SPLECHTNA, H
通讯作者：
SPLECHTNA, H
DOI：
10.1073/pnas.0801763105
发表时间：
2008-08-19
影响因子：
11.1
作者：
Gratton, Stephanie E. A.;Ropp, Patricia A.;DeSimone, Joseph M.
通讯作者：
DeSimone, Joseph M.