New concepts on the pathogenesis of fever.
New concepts on the pathogenesis of fever.
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关于发热发病机制的新概念。
DOI：
10.1093/clinids/10.1.168
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Wolff,SM
中科院分区：
文献类型：
--
作者：
Dinarello,CA;Cannon,JG;Wolff,SM
50多年来，关于发烧的实验研究一直集中在白细胞中的一种物质，称为白细胞或内源性热原。不同的研究人员得出结论，与感染相关的变化--如循环中白细胞的数量；微量金属、氨基酸和肝脏蛋白的水平；以及淋巴细胞功能的改变--也是由内源性白细胞介体引起的。有合理的证据表明，发烧和其他变化是通过单一内源性热原，即现在所知的白介素1(IL-1)的作用而引起的。IL-1的两种形式(IL-1β和IL-1α)已被克隆，对重组IL-1制剂的研究证实，发热和宿主对感染和损伤的广泛反应确实是由这种物质介导的。然而，IL-1并不是唯一引起发烧的白细胞产物：肿瘤坏死因子(Cachectin)和干扰素会在人和动物中引起发烧。因此，单一内源性热原的概念现在需要修改。自然界赋予了至少三个结构不同的分子产生发烧的能力。试图确定在特定疾病中触发下丘脑发烧的因素的研究人员现在必须考虑这三种内源性热原，无论是单独还是共同作为发烧的媒介。
For more than 50 years, experimental studies on fever have focused on a substance from leukocytes called leukocytic or endogenous pyrogen. Various investigators concluded that changes associated with infection - such as numbers of circulating leukocytes; levels of trace metals, amino acids, and hepatic proteins; and altered lymphocyte function - were also caused by endogenous leukocyte mediators. There was reasonable evidence that fever and these other changes were brought about through the action of a single endogenous pyrogen, now known as interleukin 1 (IL-1). Two forms of IL-1 have been cloned (IL-1β and IL-1α), and studies of recombinant IL-1 preparations have confirmed that fever and the broad spectrum of host responses to infection and injury are indeed mediated by this substance. However, IL-1 is not the only leukocyte product that induces fever: tumor necrosis factor (cachectin) and interferon produce fever in humans and animals. Accordingly, the concept of a single endogenous pyrogen now requires modification. Nature has conferred the ability to produce fever on no fewer than three structurally distinct molecules. Investigators trying to determine what triggers the hypothalamus to initiate fever in a particular disease must now consider these three endogenous pyrogens, either alone or together, as mediators of fever.
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人类白细胞介素 1 的四种生化特性不同的物种都表现出相似的生物活性。
影响因子：
4.4
作者：
D. Wood;E. Bayne;M. Goldring;M. Gowen;D. Hamerman;J. Humes;E. J. Ihrie;P. Lipsky;M. Staruch
通讯作者：
M. Staruch
影响因子：
4.4
作者：
S. Warner;K. Auger;P. Libby
通讯作者：
S. Warner;K. Auger;P. Libby
热潮：历史视角与现代观点的演变
DOI：
--
发表时间：
1985
期刊：
影响因子：
--
作者：
E. Atkins
通讯作者：
E. Atkins
影响因子：
39.2
作者：
H. Lane;A. Fauci
通讯作者：
A. Fauci
发热时家兔第三脑室脑脊液中前列腺素E含量及体温变化
DOI：
--
发表时间：
1980
期刊：
Journal of Physiology
影响因子：
--
作者：
H. Bernheim;T. M. Gilbert;J. Stitt
通讯作者：
J. Stitt