High Level of Serum and Cerebrospinal Fluid of Heparan Sulfate and Hyaluronic Acid Might Be a Biomarker of Severity of Neuromyelitis Optica.
High Level of Serum and Cerebrospinal Fluid of Heparan Sulfate and Hyaluronic Acid Might Be a Biomarker of Severity of Neuromyelitis Optica.
复制标题
血清和脑脊液中硫酸乙酰肝素和透明质酸的高水平可能是视神经脊髓炎严重程度的生物标志物。
DOI：
10.3389/fimmu.2021.705536
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发表时间：
2021
影响因子：
7.3
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Zhang Q;Pei S;Zhou Z;Wang Z;Peng Y;Chen J;Wang H
背景视神经脊髓炎(NMO)、多发性硬化(MS)和自身免疫性胶质纤维酸性蛋白(GFAP)星形细胞病变是以脑脊髓炎为主的特发性炎症性脱髓鞘疾病(IIDD)。硫酸乙酰肝素(HS)和透明质酸(HA)是糖基化反应的两种成分，糖基化反应是血管表面的一层碳水化合物丰富的层，介导与血液的相互作用。目前对NMO中糖的降解情况知之甚少。目的检测血清和脑脊液(CSF)中SHORD、HS和HA的水平，并与病情严重程度进行相关性分析，以确定其诊断价值。方法收集24例NMO患者、15例MS患者、10例自身免疫性GFAP星形细胞病变患者和18例非炎症性神经系统疾病患者的血清和脑脊液标本。用酶联免疫吸附试验检测血清中可溶性HS、HA、干扰素γ、白细胞介素17A、基质金属蛋白酶-1。结果这些疾病患者血清和脑脊液中HS、HA及相关细胞因子水平明显升高，而血浆MMP1水平无明显变化。值得注意的是，HS和HA水平与扩展的残疾状态量表得分呈正相关。结论在NMO、MS和自身免疫性GFAP星形细胞病变中，糖萼降解和炎症反应明显。此外，HS或HA的脱落增加可能预示着更糟糕的临床情况。此外，保护糖萼的治疗策略可能对这些疾病有效。
Background Neuromyelitis optica (NMO), multiple sclerosis (MS) and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy are idiopathic inflammatory demyelinating diseases (IIDDs) that mainly present as encephalomyelitis. Heparan sulfate (HS) and hyaluronic acid (HA) are two components of glycocalyx, a carbohydrate-rich layer on the surface of blood vessels that mediates interaction with blood. Degradation of glycocalyx in NMO is poorly understood. Purpose To detect the serum and cerebrospinal fluid (CSF) levels of shed HS and HA and to correlate these levels with disease severity to determine their diagnostic value. Methods We obtained serum and CSF samples from 24 NMO patients, 15 MS patients, 10 autoimmune GFAP astrocytopathy patients, and 18 controls without non-inflammatory neurological diseases. Soluble HS and HA, and IFNγ, IL17A, and matrix metalloproteinase (MMP) 1 were detected via ELISA. Results Serum and CSF levels of HS, HA and related cytokines but not of plasma MMP1 were significantly elevated in these diseases. Notably, HS and HA levels were positively correlated with Expanded Disability Status Scale scores. Conclusions Our results indicate glycocalyx degradation and inflammation in NMO, MS and autoimmune GFAP astrocytopathy. Moreover, increased shedding of HS or HA may indicate a worse clinical situation. Furthermore, therapeutic strategies that protect glycocalyx may be effective in these diseases.
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影响因子：
7.3
作者：
Platt MP;Agalliu D;Cutforth T
通讯作者：
Cutforth T
影响因子：
4.5
作者：
Reitsma, Sietze;Slaaf, Dick W.;Vink, Hans;van Zandvoort, Marc A. M. J.;Egbrink, Mirjam G. A. oude
通讯作者：
Egbrink, Mirjam G. A. oude
DOI：
10.1152/ajpheart.00090.2018
发表时间：
2019-03-01
影响因子：
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影响因子：
5.3
作者：
Liu, Zhuhe;Chen, Jinyu;Peng, Yu
通讯作者：
Peng, Yu
影响因子：
3.3
作者：
Setiadi, A. Francesca;Abbas, Alexander R.;Townsend, Michael J.
通讯作者：
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