Cortical direct current stimulation improves signal transmission between the motor cortices of rats
Cortical direct current stimulation improves signal transmission between the motor cortices of rats
复制标题
皮层直流电刺激改善大鼠运动皮层之间的信号传输
DOI：
10.1016/j.neulet.2020.135492
复制
发表时间：
2021
影响因子：
2.5
通讯作者：
Takashima Ichiro
中科院分区：
文献类型：
--
作者：
Kunori Nobuo;Takashima Ichiro
经颅直流电刺激是一种非侵入性脑刺激技术，目前被广泛用于改善运动和认知功能。由于电流流入大脑和/或神经网络中的信号传递，DC的神经调节作用被认为延伸到刺激部位附近和远处的脑区。然而，DC对皮质-皮质神经元传递的影响还不是很清楚。在本研究中，我们重点研究了大鼠初级运动皮质(M1)到次级运动皮质(M2)的信号传递。在直流电刺激条件下，对M1进行皮层内微刺激(ICMS)，并通过电流源密度分析检测M2区突触活动的变化。DC刺激后，M2浅层的突触输入增加，而M2深层的突触输入增加。这些结果表明，DC刺激促进了皮质神经元从M1到M2的传递，并且DC的效果可能在M1不同类型的投射神经元之间有所不同。
Transcranial direct current (DC) stimulation is a noninvasive brain stimulation technique that is now widely used to improve motor and cognitive function. The neuromodulatory effects of DC is considered to extend to nearby as well as remote brain areas from the site of stimulation because of current flowing into the brain and/or signal transmission in neuronal networks. However, the effects of DC on cortico-cortical neuronal transmission are not well known. In the present study, we focused on signal transmission from the primary (M1) to secondary (M2) motor cortex of rats. Intra-cortical microstimulation (ICMS) was applied to the M1 under DC conditions, and changes in synaptic activity in the M2 were examined using current-source density analyses. The synaptic input to the M2 superficial layers was enhanced during DC stimulation, while the synaptic input to the M2 deeper layers was increased after DC stimulation. These results suggest that DC stimulation improves cortico-cortical neuronal transmission from M1 to M2, and that the effectiveness of DC may be different among different projection neuron types in the M1.
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