Role for migratory wild birds in the global spread of avian influenza H5N8.

Role for migratory wild birds in the global spread of avian influenza H5N8.
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DOI:
10.1126/science.aaf8852
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发表时间:
2016-10-14
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Global Consortium for H5N8 and Related Influenza Viruses
Global Consortium for H5N8 and Related Influenza Viruses
中科院分区:
其他
文献类型:
--
作者:
Global Consortium for H5N8 and Related Influenza Viruses

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禽流感病毒影响家禽生产和公共卫生。H5 N8亚型(进化枝2.3.4.4)病毒在2013/2014年韩国家禽中爆发后,于2014/2015年在全球迅速传播。我们对H5 N8病毒序列、流行病学调查、水禽迁徙和家禽贸易的分析表明,长距离迁徙的鸟类在禽流感病毒的全球传播中发挥了重要作用。此外,我们发现进化枝2.3.4.4病毒的血凝素是非常混杂的,产生了具有多种神经氨酸酶亚型的重组体。提高我们对迁徙水禽中禽流感病毒绕极传播的认识,将有助于对禽流感对家禽和潜在的人类健康的威胁提供早期预警。
Avian influenza viruses affect both poultry production and public health. A subtype H5N8 (clade 2.3.4.4) virus, following an outbreak in poultry in South Korea in 2013/2014, rapidly spread worldwide in 2014/2015. Our analysis of H5N8 viral sequences, epidemiological investigations, waterfowl migration, and poultry trade showed that long-distance migratory birds can play a major role in the global spread of avian influenza viruses. Further, we found that the haemagglutinin of clade 2.3.4.4 virus was remarkably promiscuous, creating reassortants with multiple neuraminidase subtypes. Improving our understanding of the circumpolar circulation of avian influenza viruses in migratory waterfowl will help to provide early warning of threats from avian influenza to poultry, and potentially human, health.
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