Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster.
Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster.
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DOI：
10.1007/s10522-009-9227-1
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发表时间：
2010-02
期刊：
影响因子：
4.5
通讯作者：
Jafari, Mahtab
中科院分区：
文献类型：
--
作者：
Avanesian, Agnesa;Khodayari, Behnood;Felgner, Jeffery S.;Jafari, Mahtab
在用抗惊厥药物治疗的秀丽隐杆线虫中发现寿命延长，这提出了这些药物是否是有前景的抗衰老候选化合物的问题。这些化合物对神经调节的影响表明，它们也可能影响衰老的慢性疾病。拉莫三嗪是一种常用的抗惊厥药物，具有相对较好的副作用。在这项研究中，我们评估了拉莫三嗪对死亡率，寿命，代谢率和运动的影响之间的相互作用。在许多动物模型中，已经提出寿命、代谢率和运动之间存在反比关系。我们假设，这种化合物显示的生存益处与对健康寿命的有害影响有关，例如运动抑制。使用果蝇作为我们的模型系统，我们发现拉莫三嗪降低了死亡率，延长了寿命，同时减少了运动活动和代谢率降低的趋势。我们的研究结果强调了这样一种观点，即评估健康寿命对于寻求有用的抗衰老化合物至关重要。
The discovery of life extension in Caenorhabditis elegans treated with anticonvulsant medications has raised the question whether these drugs are prospective anti-aging candidate compounds. The impact of these compounds on neural modulation suggests that they might influence the chronic diseases of aging as well. Lamotrigine is a commonly used anticonvulsant with a relatively good adverse-effects profile. In this study, we evaluated the interaction between the impacts of lamotrigine on mortality rate, lifespan, metabolic rate and locomotion. It has been proposed in a wide range of animal models that there is an inverse relationship between longevity, metabolic rate, and locomotion. We hypothesized that the survival benefits displayed by this compound would be associated with deleterious effects on health span, such as depression of locomotion. Using Drosophila as our model system, we found that lamotrigine decreased mortality and increased lifespan in parallel with a reduction in locomotor activity and a trend towards metabolic rate depression. Our findings underscore the view that assessing health span is critical in the pursuit of useful anti-aging compounds.
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影响因子：
5.3
作者：
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通讯作者：
DECHAVIGNY, A
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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