Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review.
Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review.
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靶向糖酵解的天然化合物有望成为胃癌治疗药物：综述
DOI：
10.3389/fphar.2022.1004383
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
胃癌是一种常见的恶性肿瘤，严重危害人类的健康和生命。胃癌的高死亡率可归因于缺乏有效的治疗药物。即使在有氧条件下，癌细胞也利用糖酵解途径产生能量，通常称为瓦尔堡效应，这是胃癌的特征。基于糖酵解途径的新靶点的确定是治疗胃癌的可行选择，并且越来越多的证据表明植物化学物质具有广泛的抗糖酵解性质。本文综述了植物化学物质对胃癌细胞有氧糖酵解的影响及其作用机制。植物化学物质可通过PI 3 K/Akt、c-Myc、p53等信号通路有效抑制胃癌细胞有氧糖酵解，抑制细胞增殖和迁移，促进细胞凋亡。这些通路影响HIF-1α、HK 2、LDH和其他糖酵解相关蛋白的表达。本文综述了植物源性化合物治疗胃癌的研究进展，并对新药的开发进行了展望。
Gastric cancer, a common malignant disease, seriously endangers human health and life. The high mortality rate due to gastric cancer can be attributed to a lack of effective therapeutic drugs. Cancer cells utilize the glycolytic pathway to produce energy even under aerobic conditions, commonly referred to as the Warburg effect, which is a characteristic of gastric cancer. The identification of new targets based on the glycolytic pathway for the treatment of gastric cancer is a viable option, and accumulating evidence has shown that phytochemicals have extensive anti-glycolytic properties. We reviewed the effects and mechanisms of action of phytochemicals on aerobic glycolysis in gastric cancer cells. Phytochemicals can effectively inhibit aerobic glycolysis in gastric cancer cells, suppress cell proliferation and migration, and promote apoptosis, via the PI3K/Akt, c-Myc, p53, and other signaling pathways. These pathways affect the expressions of HIF-1α, HK2, LDH, and other glycolysis-related proteins. This review further assesses the potential of using plant-derived compounds for the treatment of gastric cancer and sheds insight into the development of new drugs.
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影响因子：
2.7
作者：
An J;Liu Y;Duo S;Ma X;An L;Yan Y;Ji D;Yan Y;Cheng Q;Su Z
通讯作者：
Su Z
影响因子：
3.3
作者：
Chen, Ling;Guo, Li;Sheng, Lijun
通讯作者：
Sheng, Lijun
影响因子：
4.3
作者：
Chen, Tongke;Zhao, Liqian;Wang, Lihua
通讯作者：
Wang, Lihua
影响因子：
5.9
作者：
Castellano JM;Ramos-Romero S;Perona JS
通讯作者：
Perona JS
DOI：
10.3390/molecules27031058
发表时间：
2022-02-04
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Chang X;Chen X;Guo Y;Gong P;Pei S;Wang D;Wang P;Wang M;Chen F
通讯作者：
Chen F